Experimental Immunology

Lab Data | Principal Investigator | Outline of Research

Principal Investigator

Shimon Sakaguchi

Shimon Sakaguchi

Professor | Tel +81-6-6879-4461 | Mail shimonatmarkifrec.osaka-u.ac.jp

Education history

  • 1970-1972 Kyoto University Premedical Course
  • 1972-1976 Kyoto University Medical School

Research and career history

  • 1999- Professor and Chair, Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University
  • 2007- Director, Institute for Frontier Medical Sciences, Kyoto University

Research field

  • Immunology (Immunological tolerance and autoimmune disease)

Achievements
Publications:

  • Maeda Y, Nishikawa H, Sugiyama D, Ha D, Hamaguchi M, Saito T, Nishioka M, Wing JB, Adeegbe D, Katayama I, Sakaguchi S. Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals. Science. 346:1536-1540, 2014.
  • Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S. Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease. Science. 346:363-368, 2014.
  • Wing JB, Ise W, Kurosaki T, Sakaguchi S. Regulatory T-cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4. Immunity. 41:1013-1025,2014.
  • Yamazaki S, Nishioka A, Kasuya S, Ohkura N, Hemmi H, Kaisho T, Taguchi O, Sakaguchi S, Morita A. Homeostasis of Thymus-Derived Foxp3+ Regulatory T Cells Is Controlled by Ultraviolet B Exposure in the Skin. J Immunol. 193:5488-5497, 2014 .
  • Kitagawa Y, Ohkura N, Sakaguchi S. Epigenetic control of thymic Treg-cell development. Eur. J. Immunol. 2014 Oct 28.
  • Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nago-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest A, Standley D, Date D, Sakaguchi S, and the FANTOM consortium. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation. PNAS. 111: 5289-5294, 2014.
  • Mikami N, Sakaguchi S. CD28 signals the differential control of regulatory T cells and effector T cells. Eur J Immunol. 44:955-957, 2014.
  • Miyara M, Ito Y, Sakaguchi S. TREG-cell therapies for autoimmune rheumatic diseases. Nat Rev Rheumatol. 10:543-551 2014.
  • Morikawa H, Sakaguchi S. Genetic and epigenetic basis of Treg cell development and function: From a FoxP3-centered view to an epigenome-defined view of natural Treg cells. Immunol. Rev. 259: 192-205, 2014.
  • Forrest A, ..., Morikawa H., ..., Hamaguchi M., ..., Ohkura N., ...,Sakaguchi S., ...,Hayashizaki Y, et al., A promoter level mammalian expression atlas. Nature. 507: 462-470, 2014.
  • Wing JB, Sakaguchi S. Foxp3+ Treg cells in humoral immunity. Int Immunol. 26: 61-69, 2014.
  • Nishikawa H, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Curr Opin Immunol. 27: 1-7, 2014.
  • Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jäger E, and Sakaguchi S. Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking anti-tumor immune responses in humans. PNAS. 110:17945-17950, 2013.
  • Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 500:232-236, 2013.
  • Ohkura N, Kitagawa Y, Sakaguchi S. Development and Maintenance of Regulatory T cells. Immunity. 38:414-423, 2013.
  • Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, and Sakaguchi S. Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression. PNAS, 110(23):E2116-2125, 2013.
  • Sakaguchi S, Vignali DAA, Niec, RE, Rudensky AY, and Waldmann H. Regulatory T cell plasticity and stability. Nat. Rev. Immunol. 13:461-467, 2013.
  • Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 14:307-308, 2013.
  • Ohkura N, Sakaguchi S. Treg cells acquire new directions, cytokines navigate. Immunity. 37:443-4, 2012.
  • Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S. T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for Treg cell development. Immunity. 37:785-99, 2012.
  • Noguchi, T., Kato, T., Wang, L., Maeda, Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., and Nishikawa, H. Intracellular tumor-associated antigens represent effective targets for passive immunotherapy. Cancer Res. 72:1672-1682, 2012.
  • Hamaguchi M, Sakaguchi S. Regulatory T cells expressing PPAR-γ control inflammation in obesity. Cell Metab. 16:4-6, 2012.
  • Wing JB, Sakaguchi S. Multiple treg suppressive modules and their adaptability. Front Immunol. 3:178. Epub 2012.
  • Nishikawa, H., Maeda, Y., Ishida, T., Gnjatic, S., Sato, E., Mori, F., Sugiyama, D., Ito, A., Fukumori, Y., Utsunomiya, A., Inagaki, H., Old, L. J., Ueda, R., and Sakaguchi, S. Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma. Blood. 119:3097-3104, 2012.
  • Sakaguchi, S., Benham, H., Cope, A. P., Thomas, R. T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. Immunol Cell Biol. 90:277-87, 2012.
  • Sakaguchi, S., Powrie, F., Ransohoff, R. M. Re-establishing immunological self-tolerance in autoimmune disease. Nat Med. 18:54-58, 2012.
  • Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda, N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G. A., Koshiba, T. Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match. Transpl Int. 25:97-106, 2012.
  • Yoshioka, Y., Ono, M., Osaki, M., Konishi, I., Sakaguchi, S. Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation. Eur J Immunol. 42:749-759, 2012.
  • Wing, K., Yamaguchi, T., Sakaguchi, S. Cell-autonomous and –nonautonomous functions of CTLA-4 for negative control of immune responses. Trends Immunol. 32:428-433, 2011.
  • Sakaguchi, S., Wing K. Damping by depletion. Science. 332:542-543, 2011.
  • Ohkura, N., Sakaguchi, S. Maturation of effector regulatory T cells. Nat Immunol. 12:283-284, 2011.
  • Yamaguchi, T., Wing, J. B., Sakaguchi, S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol. 23:424-430, 2011.
  • Sakaguchi, S., Tanaka, S., Tanaka, A., Ito, Y., Maeda, S., Sakaguchi, N., Hashimoto, M. Thymus, innate immunity and autoimmune arthritis: interplay of gene and environment. FEBS Lett. 585:3633-3639, 2011.
  • Wing, J. B., Sakaguchi, S. TCR diversity and Treg cells, sometimes more is more. Eur J Immunol. 41:3097-3100, 2011.
  • Ohkura, N., Hamaguchi, M., Sakaguchi, S. FOXP3(+) regulatory T cells: control of FOXP3 expression by pharmacological agents. Trends Pharmacol. Sci. 32:158-66, 2011.
  • Ohe, H., Li, Y., Nafady-Hego, H., Kayo, W., Sakaguchi, S., Wood, K., Calne, R., Uemoto, S., Koshiba, T. Minimal but essential doses of immunosuppression: A more realistic approach to improve long-term outcomes for pediatric living-donor liver transplantation. Transplantation. 91:808-810, 2011.
  • Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog. 7(2):e1001274, 2011.
  • Miyara, M., Gorochov, G., Ehrenstein, M., Musset, L., Sakaguchi, S., Amoura, Z. Human FoxP3(+) regulatory T cells in systemic autoimmune diseases. Autoimmun. Rev. 10:744-755, 2011.
  • Miyara, M., and Sakaguchi, S. FoxP3+CD4+ regulatory T cells: their knowns and unknowns. Immunol. Cell. Biology. 89:346-351, 2011.
  • Sakaguchi, S. Regulatory T cells: history and perspective. Methods in Molecular Biology. 77: 1-13, 2011.
  • Ohkura N, Sakaguchi S. Foxo1 and Foxo3 help Foxp3. Immunity. 33:835-7, 2010.
  • Fujii, H., Arakawa, A., Kitoh, A., Miyara, M., Kato, M., Kore-Eda, S., Sakaguchi, S., Miyachi, Y., Tanioka, M., and Ono, M. Perturbations of both non-regulatory and regulatory FOXP3(+) T cells in patients with malignant melanoma. Br. J. Dermatol. 164:1052-1060, 2010.
  • Sakaguchi, S. Conditional stability of T cells. Nature. 468:41-42, 2010.
  • Nafady-Hego, H., Li, Y., Ohe, H., Zhao, X., Satoda, N., Sakaguchi, S., Wood, K., Uemoto, S., and Koshiba, T. The generation of donor-specific CD4+CD25++CD45RA+ naïve regulatory T cells in operationally tolerance patients after pediatric living-donor liver transplantation. Transplantation. 90:1547-55, 2010.
  • Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato, E., Kondo, S., Allison, J. P., Sakaguchi, S., Old, L. J., Kato, T., and Shiku, H. Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. Clin. Cancer Res. 16:2781-91, 2010.
  • Nishikawa, H., and Sakaguchi, S. Regulatory T cells in tumor immunity. Int. J. Cancer. 127:759-67, 2010.
  • Ohkura, N., and Sakaguchi, S. Regulatory T cells: roles of Tcell erceptor for their development and function. Semin. Immunopathol. 32:95-106, 2010.
  • Sakaguchi, S., Miyara, M., Costantino, C. M., and Hafler, D. A. FOXP3+ regulatory T cells in the human system. Nat. Rev. Immunol. 185:2295-305, 2010.
  • Hashimoto, M., Hirota, K., Yoshitomi, H., Maeda, S., Teradaira, S., Akizuki, S., Prieto-Martin, P., Nomura, T., Sakaguchi, N., Köhl, J., Heyman, B., Takahashi, M., Fujita, T., Mimori, T., Sakaguchi, S. Complement drives Th-17 cell differentiation and triggers autoimmune disease. J. Exp. Med. 207:1135-43, 2010.
  • Tanaka, S., Maeda, S., Hashimoto. M., Teradaira, S., Hirota,K., Yoshitomi, H., Katakai, T., Shimizu, A., Nomura, T., Sakaguchi, N., and Sakaguchi, S. Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J. Immunol. 185:2295-305, 2010.
  • Wing, K., and Sakaguchi, S. Regulatory T cells exert checks and balances on self-tolerance and autoimmunity. Nat. Immunol. 11:7-13, 2010.
  • Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T. Regulatory T cells: how do they suppress immune responses? Int. Immunol. 21:1105-11, 2009.
  • Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S. Indispensable role of Runx1/Cbfb complexes for in vivo suppressive function of FoxP3+ regulatory T cells. Immunity. 31:609-620, 2009.
  • Sakaguchi, S., Wing, K., and Yamaguchi, T. Dynamics of peripheral tolerance and immune regulation. Eur. J. Immunol. 39(9):2331-6, 2009.
  • Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T. Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum. 60:2294-2303, 2009.
  • Miyara, M., Wing, K., and Sakaguchi, S. Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. J Allergy Clin Immunol. 123:749-55, 2009.
  • Ohkura, N,. and Sakaguchi, S. A novel modifier of regulatory T cells Nat Immunol. 10: 685-686, 2009.
  • Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., and Sakaguchi, S. Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor. Immunity. 30:899-911, 2009.
  • Nagahama, K., Fehervari, Z., Oida, T., Ogawa, O., and Sakaguchi, S. Differential control of alloantigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. Int.Immunol. 21:379-391, 2009.
  • Yoshitomi, M., Koshiba, T., Haga, H., Li, Y., Zhao, X., Cheng, D., Miyagawa, A., Sakashita, H., Tsuruyama T., Ueda, M., Wood, K., Sakaguchi S., Manabe, T., Tanaka, K., and Uemoto, S. Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation. Transplantation. 87:606-614, 2009.
  • Wing K, and Sakaguchi S. Regulatory T cells. In Clinical Immunology, eds. R. R. Rich, T. A. Fleisher, W. T. Shearer, H. W. Schroeder, Jr., A. J. Frew, and C. M. Weyand, Mosby. 2008; P249-258.
  • Miyara, M., and Sakaguchi, S. Regulatory T Cells and the Control of Auto-Immunity: From day 3 Thymectomy to FoxP3+ Regulatory T Cells. In Regulatory T cells and Clinical Application, Ed. S. Jiang, Springer, p3-16, 2008.
  • Sakihama T, Sato T, Iwanari H, Kitamura T, Sakaguchi S, Kodama T, Hamakubo T. A simple detection method for low-affinity membrane protein interactions by baculoviral display. PLoS ONE. 2008;3(12):e4024.
  • Satoda N, Shoji T, Wu Y, Fujinaga T, Chen F, Aoyama A, Zhang JT, Takahashi A, Okamoto T, Matsumoto I, Sakai H, Li Y, Zhao X, Manabe T, Kobayashi E, Sakaguchi S, Wada H, Ohe H, Uemoto S, Tottori J, Bando T, Date H, Koshiba T. Value of FOXP3 Expression in Peripheral Blood as Rejection Marker After Miniature Swine Lung Transplantation. J. Heart Lung Transplant. 27:1293-1301, 2008.
  • Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 322:271-275, 2008.
  • Li, Y., Zhao, X., Cheng, D., Haga, H., Tsuruyama, T., Wood, K., Sakaguchi, S., Tanaka, K., Uemoto, S., and Koshiba, T. The presence of FOXP3 expressing T cells within grafts of tolerance human liver transplant recipients. Transplantation. 86:1837-1843,2008
  • Wakasa-Morimoto, C., Toyosaki-Maeda, T., Matsutani, T., Yoshida, R., Nakamura-Kikuoka, S., Maeda-Tanimura, M., Yoshitomi, H., Hirota, K., Hashimoto, H., Masaki, H., Fujii, F., Sakata, T., Tsuruta, Y., Suzuki, R., Sakaguchi, N., and Sakaguchi, S. Arthritis and pneumonitis produced by the same T-cell clones from mice with spontaneous autoimmune arthritis. Int. Immunol. 20:1331-1342, 2008.
  • Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S. Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA. 29:10113-10118, 2008.
  • Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M. Regulatory T cells and immune tolerance. Cell. 133: 775-787, 2008.
  • Sakaguchi, S. Regulatory T cells in the past and for the future. Eur. J. Immunol. 38:901-937, 2008.
  • Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, Nomura T, Sakaguchi S. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity. 27:145-159, 2007.
  • Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S. Foxp3 controls regulatory T cell function via interacting with AML1/Runx1. Nature. 446:685-689, 2007.
  • Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S. Preferential recruitment of arthritogenic Th17 cells to inflamed joints via CCR6/CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204:2803-2812, 2007
  • Sakaguchi S, Powrie F. Emerging challenges in regulatory T cell function and biology. Science. 317:627-629, 2007.
  • Sakaguchi S, Wing K, Miyara M. Regulatory T cells in brief history and perspective. Eur. J. Immunol. 37:s116-123, 2007
  • Nomura T, Sakaguchi S. Foxp3 and Aire in thymus-generated T(reg) cells: a link in self-tolerance. Nat Immunol. 8:333-334, 2007.
  • Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med. 13:108-116, 2007.
  • Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med. 204:41-47, 2007.
  • Yamaguchi T, Sakaguchi S. Skin controls immune regulators. Nat Med. 12:1358-1359, 2006.
  • Katakai T, Nomura T, Gonda H, Sugai M, Agata Y, Nishio A, Masuda T, Sakaguchi S, Shimizu A. Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+-ATPase-Reactive TCR Transgenic Mouse. J Immunol. 177:7858-67, 2006.
  • Wing, K. and Sakaguchi, S. Regulatory T cells in allergy. Curr. Opin. Allergy and Immunol. 6:482-8, 2006.
  • Fehervari, Z. and Sakaguchi, S. Peacekeepers of the immune system. Sci Am. 295:56-63, 2006.
  • Wing, K., Fehervari, Z., and Sakaguchi, S. Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18:991-1000, 2006.
  • Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., and Sakaguchi, S. Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol. 18:1197-1209, 2006.
  • Nishioka, T., Shimizu, J, Iida, R., Yamazaki, S., and Sakaguchi, S. CD4+ CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J. Immunol. 176:6586-6593, 2006.
  • Sakaguchi, S., Ono, M., Setoguchi, R., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T., and Nomura, T. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212:8-27, 2006.
  • Ono, M., Shimizu, J., Miyachi, Y., and Sakaguchi, S. Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing naturally arising CD4+ regulatory T cells. J. Immunol. 176:4748-4756, 2006.
  • Fehervari, Z., Yamaguchi, T., and Sakaguchi, S. The dichotomous roles of IL-2: tolerance versus immunity. Trends Immunol. 27:109-111, 2006.
  • Sakaguchi, S., Sakaguchi, N., Yoshitomi, H., Hata, H., Takahashi, T., and Nomura, T. Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1. Semin. Immunol. 18:199-206, 2006.
  • Yamaguchi, T. and Sakaguchi, S. Regulatory T cells in immune surveillance and treatment of cancer. Semin. Cancer Biol. 16:115-123, 2006.
  • Sakaguchi, S., Takahashi, T., Hata, H., Yoshitomi, H., Tanaka, S., Hirota, K., Nomura, T., and Sakaguchi, N. SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T cells. In The hereditary Basis of Rheumatic Diseases, Progress in Inflammation Research. Edited by RikardHolmdahl, Birkhaeuser Verlag, Basel, p147-159, 2006.
  • Sakaguchi, S., Setoguchi, R., Yagi, H., and Nomura, T. Naturallyarising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. Curr Top Microbiol Immunol. 305:51-66, 2006.
  • Fehervari, Z. and Sakaguchi, S. T lymphocytes: Regulatory. Nature Encyclopedia of Life Sciences. Wiley Interscience, 2006. Available at www.els.net.
  • Sakaguchi, S., Sakaguchi, N. Animal models of arthritis caused by systemic alteration of the immune system. Curr Opin Immunol. 17: 589-594, 2005.
  • Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., and Sakaguchi, S. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J. Exp. Med. 202: 885-891, 2005.
  • Nishikawa, H., Kato, T., Tawara, I., Saito, K., Ikeda, H., Kuribayashi, K., Allen, P. M., Schreiber, R. D., Sakaguchi, S., Old, L. J., Shiku, H. Definition of target antigens for naturally occurring CD4+CD25+ regulatory T cells. J. Exp. Med. 201: 681-686, 2005.
  • Sakaguchi, S., and Sakaguchi, N. History of CD25+CD4+ regulatory T cells. In Regulatory T cells in inflammation, Progress in Inflammation Research. Eds. L. S. Taams, A. N. Akbar, and M. H. M. Wauben, Birkhaeuser Verlag, Basel, p3-17, 2005.
  • Nomura, T., and Sakaguchi, S. Regulatory T cells in tumor immunity. Curr Top Microbiol Immunol. 293:287-302, 2005.
  • Sakaguchi, S. and Sakaguchi, N. Regulatory T cells in immunologic self-tolerance and autoimmune diseases. Int. Rev. Immunol. 24:211-226, 2005.
  • Fehervari Z, Sakaguchi S. CD4+ regulatory cells as a potential Immunotherapy. Philos Trans R Soc Lond B Biol Sci. 360:1647-1661, 2005.
  • Sakaguchi, S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352, 2005.
  • Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M. Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice. J. Immunol. 174:1862-1870, 2005.
  • Setoguchi, R., Hori, S., Takahashi, T., and Sakaguchi, S. Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization J. Exp. Med. 201:723-735, 2005.
  • Yoshitomi, H., Sakaguchi, N., Brown, G., Tagami, T., Sakihama,T., Nomura, T., Akira, S., Gordon, S., Nakamura, T., and Sakaguchi, S. Environmental stimulation of innate immunity triggers chronic arthritis in mice genetically prone to produce arthritogenic autoimmune T cells: a key role of fungal β-glucans and their receptor Dectin-1. J. Exp. Med. 201: 949-960, 2005.
  • Fehervari, Z., and Sakaguchi, S.: Regulatory T cells. In Measuring Immunity, eds. M. T. Lotze and A. W. Thompson, Elsevier. p322-335, 2005. Fehervari, Z., and Sakaguchi, S. CD4+ regulatory T cells and immune control. J. Clin. Invest. 114:1209-117, 2004.
  • Yagi, H., Nomura, T., Nakamura, K., Kitawaki, T., Hori, S., Maeda, M., Onodera, M., Uchiyama, T., Fujii, S., and Sakaguchi, S. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16: 1643-1656, 2004.
  • Kanamaru, F., Youngnak, P., Hashiguchi, M., Nishioka, T., Takahashi, T., Sakaguchi, S., Ishikawa, I., and Azuma, M. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J. Immunol. 172: 7306-7314, 2004.
  • Fehervari, Z., and Sakaguchi, S.: Control of CD25+CD4+ regulatory T cell activation and function by dendritic cells. Int. Immunol. 16:1769-1780, 2004.
  • Hata, H., Sakaguchi, N., Yoshitomi, H., Iwakura, Y., Sekikawa, K., Rennick, D., Azuma, Y., Kanai, C., Moriizumi, E., Nakamura, T., and Sakaguchi, S. Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J. Clin. Invest. 114: 582-588, 2004.
  • Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka. K., and Sakaguchi, S. Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising CD25+CD4+ regulatory T cells. Int. Immunol. 16: 1189-1201, 2004.
  • Dittmer, U., He, H., Messer, R. J., Schimmer, S., Olbrich, A. R., Ohlen, C., Greenberg, P. D., Stromnes, I. M., Iwashiro, M., Sakaguchi, S., Evans, L. H., Peterson, K. E., Yang, G., Hasenkrug, K. J. Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral infection. Immunity. 20: 1-20, 2004.
  • Fehervari, Z., and Sakaguchi, S. Development and function of CD25+CD4+ regulatory T cells. Curr Opin Immunol. 16:203-208, 2004.
  • Hori, S., and Sakaguchi, S. Foxp3, a critical regulator of regulatory T cell development and function. Microbes Infect. 6: 745-51, 2004.
  • Sakaguchi, S.: Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531-562, 2004.
  • Kajiura, F., S. Sun, T. Nomura, K. Izumi, T. Ueno, Y. Bando, N. Kuroda, H. Han, Yi Li, A. Matsushima, Y. Takahama, S. Sakaguchi, T. Mitani and M. Matsumoto. NF-kB-inducing kinase establishes self-tolerance in a thymic-stroma dependent manner. J. Immunol. 172: 2067-2075, 2004.
  • Sakaguchi, S. The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J. Clin. Invest. 112: 1310-1312, 2003.
  • Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T., Tagami, T., Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I., Nakatsuru, S., and Sakaguchi, S. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 426:454-60, 2003
  • Sakaguchi, S. Taming transplantation by regulatory T cells. Nat Med. 9:1117-1118, 2003.
  • Takahashi, T. and Sakaguchi, S. Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease. Curr. Mol. Med. 3: 693-706, 2003.
  • Hori, S., Takahashi, T., and Sakaguchi, S. Control of autoimunity by natural regulatory T cells. Adv. Immunol. 81: 329-369, 2003.
  • Sakaguchi, S. Control of immune responses by naturally arising CD4+ regulatory T cells. J. Exp. Med. 197: 397-401, 2003
  • Hori, S., Nomura, T., and Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299: 1057-1061, 2003.
  • Wood, K. and Sakaguchi, S. Regulatory T cells in transplantation. Nat. Rev. Immunol. 3: 199-210, 2003.
  • Sakaguchi, S. Regulatory T cells: mediating compromises between host and parasite. Nat Immunol. 4: 10-11, 2003.
  • Takahashi, T., and Sakaguchi, S. The role of regulatory T cells in controlling immunologic self-tolerance. Int. Rev. Cytol. 225: 1-32, 2003.

Prize:

  • Mochida Science Award (2003)
  • Cancer Research Institute's William B. Coley Award for Basic Immunology and Tumor Immunology (2004)
  • Takeda Medical Award (2005)
  • Takamine Memorial Sankyo Award (2005)
  • The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (2007)
  • Uehara Memorial Award (2008)
  • The Keio Medical Science Prize (2008)
  • The Emperor's Purple Ribbon Medal (2009)
  • Asahi prize (2012)
  • The Japan Academy (2012)
  • Foreign Associate of NAS, USA (2012)
  • Maharshi Sushruta Award (2015)
  • Gairdner International Award (2015)
  • Chunichi Award (2015)

Special mention
Editorial Board

  • Science (Reviewing Editor)
  • Journal of Experimental Medicine (Advisory Editor)
  • Immunity (Editorial Board)
  • Immunological Reviews (Editorial Board)
  • International Immunology (Advisory Editor)
  • Journal of Experimental Pathology (Advisory Editor)
  • Cancer Immunity (Associate Editor)
  • eLife (Editorial Board)

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