Nuclear Medicine

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We have developed original integrated PET/MRI system. Simultaneous scanning of PET/MRI system creates a new fusion of morphological and functional imaging.

Principal Investigator

Jun Hatazawa Professor

Research field:
  • Cerebral blood flow and metabolism
  • Neurotransmission
  • Brain function
  • Molecular imaging
  • Integrated PET/MRI system
  • PET/SPECT analysis
  • New isotope tracer
hatazawa atmark
Education history
1979Tohoku University School of Medicine, March
1983.3Tohoku University Graduate School of Medicine
Research and career history
1987.1-1991.5Cyclotron Radioisotope Center of Tohoku University
1991.5-2001.4Chief Research Staff, Research Institute for Brain and Blood Vessels Akita
2001.5-2002.5Research Director, Research Institute for Brain and Blood Vessels Akita


Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y. 11C-Acetate PET Imaging in Patients with Multiple Sclerosis. PLoS One. 2014 Nov 4;9(11):e111598.
Sakane M, Tatsumi M, Kim T, Hori M, Onishi H, Nakamoto A, Eguchi H, Nagano H, Wakasa K, Hatazawa J, Tomiyama N. Correlation between apparent diffusion coefficients on diffusion-weighted MRI and standardized uptake value on FDG-PET/CT in pancreatic adenocarcinoma. Acta Radiol. 2014 Sep 29. (in press)
Watabe T, Naka S, Ikeda H, Horitsugi G, Kanai Y, Isohashi K, Ishibashi M, Kato H, Shimosegawa E, Watabe H, Hatazawa J. Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat. PLoS One. 2014 Sep 16;9(9):e107427.
Yamamoto S, Hamamura F, Watabe T, Ikeda H, Kanai Y, Watabe H, Kato K, Ogata Y, Hatazawa J. Development of a PET/Cerenkov-light hybrid imaging system. Med Phys. 2014 Sep;41(9):092504.
Yamamoto S, Watabe T, Ikeda H, Kanai Y, Watabe H, Ogata Y, Kato K, Hatazawa J. Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations. Ann Nucl Med. 2014 Aug 8. (in press)
Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Tatsumi M, Kitagawa K, Fujinaka T, Yoshimine T, Hatazawa J. Paradoxical reduction of cerebral blood flow after acetazolamide loading: a hemodynamic and metabolic study with (15)O PET. Neurosci Bull. 2014 Oct;30(5):845-56.
Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Hatazawa J. CBF/CBV maps in normal volunteers studied with (15)O PET: a possible index of cerebral perfusion pressure. Neurosci Bull. 2014 Oct;30(5):857-62.
Hanamoto A, Tatsumi M, Takenaka Y, Hamasaki T, Yasui T, Nakahara S, Yamamoto Y, Seo Y, Isohashi F, Ogawa K, Hatazawa J, Inohara H. Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy. Cancer Med. 2014 Oct;3(5):1368-76.
Yamauchi M, Imabayashi E, Matsuda H, Nakagawara J, Takahashi M, Shimosegawa E, Hatazawa J, Suzuki M, Iwanaga H, Fukuda K, Iihara K, Iida H. Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of (123)I-iodoamphetamine: comparison among data acquired at three institutions. Ann Nucl Med. 2014 Jul 8. (in press)
Hosono M, Saga T, Ito K, Kumita S, Sasaki M, Senda M, Hatazawa J, Watanabe H, Ito H, Kanaya S, Kimura Y, Saji H, Jinnouchi S, Fukukita H, Murakami K, Kinuya S, Yamazaki J, Uchiyama M, Uno K, Kato K, Kawano T, Kubota K, Togawa T, Honda N, Maruno H, Yoshimura M, Kawamoto M, Ozawa Y. Clinical practice guideline for dedicated breast PET. Ann Nucl Med. 2014 Jul;28(6):597-602.
Tamura M, Matsui H, Hirohara S, Kakiuchi K, Tanihara M, Takahashi N, Nakai K, Kanai Y, Watabe H, Hatazawa J. Selective accumulation of [?2Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells. Bioorg Med Chem. 2014 Apr 15;22(8):2563-70.
Tsuboyama T, Tatsumi M, Onishi H, Nakamoto A, Kim T, Hori M, Sakane M, Hori Y, Morii E, Hatazawa J, Tomiyama N. Assessment of combination of contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography for evaluation of ovarian masses. Invest Radiol. 2014 Aug;49(8):524-31.
Yamamoto S, Watabe H, Kanai Y, Kato K, Hatazawa J. Development of a high-resolution YSO gamma camera system that employs 0.8-mm pixels. Ann Nucl Med. 2014 Apr;28(3):232-40.
Miyata H, Yamasaki M, Takahashi T, Murakami K, Tanaka K, Yukinori K, Nakajima K, Takiguchi S, Morii E, Hatazawa J, Mori M, Doki Y. Determinants of response to neoadjuvant chemotherapy for esophageal cancer using 18F-fluorodeoxiglucose positron emission tomography (18F-FDG-PET). Ann Surg Oncol. 2014 Feb;21(2):575-82.
Yamamoto S, Watabe H, Kanai Y, Watabe T, Kato K, Hatazawa J. Development of an ultrahigh resolution Si-PM based PET system for small animals. Phys Med Biol. 2013 Nov 7;58(21):7875-88.
Ito K, Mori E, Fukuyama H, Ishii K, Washimi Y, Asada T, Mori S, Meguro K, Kitamura S, Hanyu H, Nakano S, Matsuda H, Kuwabara Y, Hashikawa K, Momose T, Uchida Y, Hatazawa J, Minoshima S, Kosaka K, Yamada T, Yonekura Y; J-COSMIC Study Group. Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study. Ann Nucl Med. 2013 Dec;27(10):898-906.
Hanamoto A, Takenaka Y, Shimosegawa E, Ymamamoto Y, Yoshii T, Nakahara S, Hatazawa J, Inohara H. Limitation of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) to detect early synchronous primary cancers in patients with untreated head and neck squamous cell cancer. Ann Nucl Med. 2013 Dec;27(10):880-5.
Toita R, Kanai Y, Watabe H, Nakao K, Yamamoto S, Hatazawa J, Akashi M. Biodistribution of (125)I-labeled polymeric vaccine carriers after subcutaneous injection. Bioorg Med Chem. 2013 Sep 1;21(17):5310-5.
Shimosegawa E, Fujino K, Kato H, Hatazawa J. Quantitative CBF measurement using an integrated SPECT/CT system: validation of three-dimensional ordered-subset expectation maximization and CT-based attenuation correction by comparing with O-15 water PET. Ann Nucl Med. 2013 Nov;27(9):822-33.
Hosoya T, Hatazawa J, Sato S, Kanoto M, Fukao A, Kayama T. Floating Dural Sac Sign is a Sensitive Magnetic Resonance Imaging Finding of Spinal Cerebrospinal Fluid Leakage. Neurol Med Chir (Tokyo). 2013;53(4):207-12.
Isohashi K, Shimosegawa E, Kato H, Kanai Y, Naka S, Fujino K, Watabe H, Hatazawa J. Optimization of [11C]methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV. EJNMMI Res. 2013 Apr 15;3(1):27.
Watabe T, Shimosegawa E, Watabe H, Kanai Y, Hanaoka K, Ueguchi T, Isohashi K, Kato H, Tatsumi M, Hatazawa J. Quantitative Evaluation of Cerebral Blood Flow and Oxygen Metabolism in Normal Anesthetized Rats: 15O-Labeled Gas Inhalation PET with MRI Fusion. J Nucl Med. 2013 Feb;54(2):283-90.
Hosomi K, Kishima H, Oshino S, Hirata M, Tani N, Maruo T, Khoo HM, Shimosegawa E, Hatazawa J, Kato A, Yoshimine T. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res. 2013 Feb;103(2-3):195-204.