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Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals (Shimon SAKAGUCHI in Science)

The authors found Treg can render self-reactive human CD8+ T cells anergic (i.e., hypoproliferative and cytokine hypoproducing upon antigen restimulation) in vitro, likely by controlling the costimulatory function of antigen-presenting cells.

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Shimon SAKAGUCHI

Shimon SAKAGUCHI(Experimental Immunology)

Tel 06-6879-4461 Mail shimonatmarkifrec.osaka-u.ac.jp

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