Osteoprotection by semaphorin 3A (Hiroshi TAKAYANAGI (TMDU) & Atsushi KUMANOGOH (IFReC) in Nature) | Apr. 22, 2012 |
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The authors show that semaphorin 3A (Sema3A) exerts an osteoprotective effect by both suppressing osteoclastic bone resorption and increasing osteoblastic bone formation.
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Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival (TOYOFUKU & KUMANOGOH in Genes and Development) | Mar. 31, 2012 |
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The authors report that Semaphorin 4A (Sema4A), a member of axonal guidance molecule semaphorin, plays a role in Rab11/FIP2-mediated endosomal sorting in retinal pigment epithelial cells to support photoreceptor function.
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Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. | Mar. 6, 2012 |
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The authors report that intestinal CX3C chemokine receptor 1high (CX3CR1high) CD11b+ CD11c+ cells are responsible for prevention of intestinal inflammation through inhibition of T-cell responses.
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Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. (Masaaki MURAKAMI in Cell) | Feb. 3, 2012 |
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The authors show that autoreactive T cells access the central nervous system via the fifth lumbar spinal cord.
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The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. (Shizuo AKIRA in Nat Immunol.) | Oct. 31, 2011 |
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The authors show that the IKK complex controlled the stability of mRNA for interleukin 6 (IL-6) by phosphorylating regnase-1 in response to stimulation via the IL-1 receptor (IL-1R) or TLR.
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The article by Dr. Noel Verjan & Prof. Miyasaka was featured in "In This Issue" of The Journal of Immunology. | Aug. 20, 2011 |
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"In This Issue" of The Journal of Immunology means highlights articles that are among the top 10% of articles published in the journal.
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Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis (Tadamitsu Kishimoto in PNAS) | Aug. 8, 2011 |
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The authors report we show that Ahr deficiency ameliorated collagen-induced arthritis, a mouse model of RA. Collagen-immunized Ahr KO mice showed decreased serum levels of such proinflammatory cytokines as IL-1β and IL-6. The Th17 and Th1 cell populations in lymph nodes from these mice decreased and increased, respectively, whereas the percentage of regulatory T cells was unchanged.
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DNA released from dying host cells mediates aluminum adjuvant activity. (Ken Ishii in Nature Medicine) | Jul. 15, 2011 |
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The authors report that, in mice, alum causes cell death and the subsequent release of host cell DNA, which acts as a potent endogenous immunostimulatory signal mediating alum adjuvant activity. Furthermore, they propose that host DNA signaling differentially regulates IgE and IgG1 production after alum-adjuvanted immunization.
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CIN85 drives B cell responses by linking BCR signals to the canonical NF- kB pathway. (Tomohiro Kurosaki in JEM) | Jun. 23, 2011 |
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The authors showed that CIN85, an adaptor protein which binds the C-terminal domain of tyrosine phosphorylated Cbl and Cbl-b links the BCR to IKK-beta activation, thereby contributing to T cell-independent immune responses.
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ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18. (Kiyoshi Takeda & Masahiro Yamamoto in JEM) | Jun. 14, 2011 |
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The ROP18 kinase has been identified as a key virulence determinant conferring a high mortality phenotype characteristic of type I Toxoplasma gondii strains. The authors show that ROP18 targets the host endoplasmic reticulum-bound transcription factor ATF6β.
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