核医学

Nuclear Medicine

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当研究室では独自のPET/MRI一体型装置の開発・研究を行っている。小動物モデルでのPET・MRI同時撮像を行い、形態画像と機能画像との融合による新たなイメージングを開拓する。

主任研究者

畑澤 順 教授

研究内容:脳循環代謝、神経伝達、脳機能 分子イメージング PET/MRI一体型装置 PET/SPECT画像解析 新規トレーサ
06-6879-3461
hatazawarcnp.osaka-u.ac.jp
学 歴
1979東北大学 医学部卒
1983東北大学 医学研究科 博士 修了 医学博士
職 歴
1987東北大学サイクロトロンラジオアイソトープセンター・助手
1991秋田県立脳血管研究センター・主任研究員
2001秋田県立脳血管研究センター・研究部長
2002.6~2019.3大阪大学医学系研究科,教授
2010.4~大阪大学免疫学フロンティア研究センター 主任研究者(兼)
2019.4~核物理研究センター,特任教授
 

主な論文

Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y. 11C-Acetate PET Imaging in Patients with Multiple Sclerosis. PLoS One. 2014 Nov 4;9(11):e111598.
Sakane M, Tatsumi M, Kim T, Hori M, Onishi H, Nakamoto A, Eguchi H, Nagano H, Wakasa K, Hatazawa J, Tomiyama N. Correlation between apparent diffusion coefficients on diffusion-weighted MRI and standardized uptake value on FDG-PET/CT in pancreatic adenocarcinoma. Acta Radiol. 2014 Sep 29. (in press)
Watabe T, Naka S, Ikeda H, Horitsugi G, Kanai Y, Isohashi K, Ishibashi M, Kato H, Shimosegawa E, Watabe H, Hatazawa J. Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat. PLoS One. 2014 Sep 16;9(9):e107427.
Yamamoto S, Hamamura F, Watabe T, Ikeda H, Kanai Y, Watabe H, Kato K, Ogata Y, Hatazawa J. Development of a PET/Cerenkov-light hybrid imaging system. Med Phys. 2014 Sep;41(9):092504.
Yamamoto S, Watabe T, Ikeda H, Kanai Y, Watabe H, Ogata Y, Kato K, Hatazawa J. Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations. Ann Nucl Med. 2014 Aug 8. (in press)
Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Tatsumi M, Kitagawa K, Fujinaka T, Yoshimine T, Hatazawa J. Paradoxical reduction of cerebral blood flow after acetazolamide loading: a hemodynamic and metabolic study with (15)O PET. Neurosci Bull. 2014 Oct;30(5):845-56.
Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Hatazawa J. CBF/CBV maps in normal volunteers studied with (15)O PET: a possible index of cerebral perfusion pressure. Neurosci Bull. 2014 Oct;30(5):857-62.
Hanamoto A, Tatsumi M, Takenaka Y, Hamasaki T, Yasui T, Nakahara S, Yamamoto Y, Seo Y, Isohashi F, Ogawa K, Hatazawa J, Inohara H. Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy. Cancer Med. 2014 Oct;3(5):1368-76.
Yamauchi M, Imabayashi E, Matsuda H, Nakagawara J, Takahashi M, Shimosegawa E, Hatazawa J, Suzuki M, Iwanaga H, Fukuda K, Iihara K, Iida H. Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of (123)I-iodoamphetamine: comparison among data acquired at three institutions. Ann Nucl Med. 2014 Jul 8. (in press)
Hosono M, Saga T, Ito K, Kumita S, Sasaki M, Senda M, Hatazawa J, Watanabe H, Ito H, Kanaya S, Kimura Y, Saji H, Jinnouchi S, Fukukita H, Murakami K, Kinuya S, Yamazaki J, Uchiyama M, Uno K, Kato K, Kawano T, Kubota K, Togawa T, Honda N, Maruno H, Yoshimura M, Kawamoto M, Ozawa Y. Clinical practice guideline for dedicated breast PET. Ann Nucl Med. 2014 Jul;28(6):597-602.
Tamura M, Matsui H, Hirohara S, Kakiuchi K, Tanihara M, Takahashi N, Nakai K, Kanai Y, Watabe H, Hatazawa J. Selective accumulation of [?2Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells. Bioorg Med Chem. 2014 Apr 15;22(8):2563-70.
Tsuboyama T, Tatsumi M, Onishi H, Nakamoto A, Kim T, Hori M, Sakane M, Hori Y, Morii E, Hatazawa J, Tomiyama N. Assessment of combination of contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography for evaluation of ovarian masses. Invest Radiol. 2014 Aug;49(8):524-31.
Yamamoto S, Watabe H, Kanai Y, Kato K, Hatazawa J. Development of a high-resolution YSO gamma camera system that employs 0.8-mm pixels. Ann Nucl Med. 2014 Apr;28(3):232-40.
Miyata H, Yamasaki M, Takahashi T, Murakami K, Tanaka K, Yukinori K, Nakajima K, Takiguchi S, Morii E, Hatazawa J, Mori M, Doki Y. Determinants of response to neoadjuvant chemotherapy for esophageal cancer using 18F-fluorodeoxiglucose positron emission tomography (18F-FDG-PET). Ann Surg Oncol. 2014 Feb;21(2):575-82.
Yamamoto S, Watabe H, Kanai Y, Watabe T, Kato K, Hatazawa J. Development of an ultrahigh resolution Si-PM based PET system for small animals. Phys Med Biol. 2013 Nov 7;58(21):7875-88.
Ito K, Mori E, Fukuyama H, Ishii K, Washimi Y, Asada T, Mori S, Meguro K, Kitamura S, Hanyu H, Nakano S, Matsuda H, Kuwabara Y, Hashikawa K, Momose T, Uchida Y, Hatazawa J, Minoshima S, Kosaka K, Yamada T, Yonekura Y; J-COSMIC Study Group. Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study. Ann Nucl Med. 2013 Dec;27(10):898-906.
Hanamoto A, Takenaka Y, Shimosegawa E, Ymamamoto Y, Yoshii T, Nakahara S, Hatazawa J, Inohara H. Limitation of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) to detect early synchronous primary cancers in patients with untreated head and neck squamous cell cancer. Ann Nucl Med. 2013 Dec;27(10):880-5.
Toita R, Kanai Y, Watabe H, Nakao K, Yamamoto S, Hatazawa J, Akashi M. Biodistribution of (125)I-labeled polymeric vaccine carriers after subcutaneous injection. Bioorg Med Chem. 2013 Sep 1;21(17):5310-5.
Shimosegawa E, Fujino K, Kato H, Hatazawa J. Quantitative CBF measurement using an integrated SPECT/CT system: validation of three-dimensional ordered-subset expectation maximization and CT-based attenuation correction by comparing with O-15 water PET. Ann Nucl Med. 2013 Nov;27(9):822-33.
Hosoya T, Hatazawa J, Sato S, Kanoto M, Fukao A, Kayama T. Floating Dural Sac Sign is a Sensitive Magnetic Resonance Imaging Finding of Spinal Cerebrospinal Fluid Leakage. Neurol Med Chir (Tokyo). 2013;53(4):207-12.
Isohashi K, Shimosegawa E, Kato H, Kanai Y, Naka S, Fujino K, Watabe H, Hatazawa J. Optimization of [11C]methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV. EJNMMI Res. 2013 Apr 15;3(1):27.
Watabe T, Shimosegawa E, Watabe H, Kanai Y, Hanaoka K, Ueguchi T, Isohashi K, Kato H, Tatsumi M, Hatazawa J. Quantitative Evaluation of Cerebral Blood Flow and Oxygen Metabolism in Normal Anesthetized Rats: 15O-Labeled Gas Inhalation PET with MRI Fusion. J Nucl Med. 2013 Feb;54(2):283-90.
Hosomi K, Kishima H, Oshino S, Hirata M, Tani N, Maruo T, Khoo HM, Shimosegawa E, Hatazawa J, Kato A, Yoshimine T. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res. 2013 Feb;103(2-3):195-204.