Immune Homeostasis

TEL +81-6-6879-4932


Homeostasis is the system to maintain regulated variables (body temperature, blood glucose, tissue size, and so on) within acceptable ranges. Immune system can be considered as a type of homeostatic mechanism in order to keep our body harmless. Our goal is to understand the mechanisms of tissue homeostasis and immune homeostasis as well as the mechanisms of diseases caused by the abnormality/exaggeration of homeostatic regulation.


Principal Investigator

Yasutaka Okabe Associate Professor

Research field

1. Mechanisms of Tissue-Resident Macrophage Diversity
2. Immune Systems of Body Cavity
3. Mechanisms of Airway Homeostasis

Education history

2000 Waseda University, B.A.
2002 Waseda University Graduate School, M.A.
2006 Osaka University Graduate School, Ph.D.

Research and career history

2004 Young Scientist Research Fellow, JAPAN Society for the Promotion of Science (-2006)
2006 Post-doctoral fellow, Osaka University Graduate School (-2007)
2007 Post-doctoral fellow, Kyoto University Graduate School (-2008)
2008 Post-doctoral fellow, Yale University School of Medicine (-2012)
2010 Overseas Research Fellow, JAPAN Society for the Promotion of Science (-2012)
2012 Associate Research Scientist, Yale University School of Medicine (-2016)
2016 Program-Specific Associate Professor, Institute for Frontier Life and Medical Sciences, Kyoto University (-2020)
2019 PRESTO Researcher, JAPAN Science and Technology Agency
2020 Specially Appointed Associate Professor, IFReC, Osaka University


2006 Yamamura Award (Osaka Univesity)
2015 Commendation for Young Scientists (Ministry of Education, Culture, Sports, Science and Technology, JAPAN)
2016 Kishimoto Fellow (Japanese Society for Immunology)


  • Yasutaka Okabe Associate Professor
  • Noriko Shinjyo Postdoctoral fellow
  • Haruna Kimura Technical Assistant
  • Tomomi Yoshihara Technical Assistant



  • Okabe Y.
    Molecular Control of the Identity of Tissue-Resident Macrophages International Immunology, 30, 485-491, 2018
  • Okabe Y., & Medzhitov R.
    Tissue Biology Perspective on Macrophages. Nature Immunology, 17, 9-17, 2016
  • Okabe Y., & Medzhitov R.
    Tissue-specific signals control reversible program of localization and functional polarization of macrophages, Cell, 157, 832-844, 2014
  • Okabe Y., Sano T., & Nagata S.
    Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature, 460, 520-524, 2009
  • Okabe Y., Kawane K., & Nagata S.
    IFN regulatory factor (IRF) 3/7-dependent and –independent gene induction by mammalian DNA that escapes degradation European Journal of Immunology, 38, 3150-3158, 2008
  • Okabe Y., Kawane K., Akira S., Taniguchi T., & Nagata S.
    Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation The Journal of Experimental Medicine, 202, 1333-1339, 2005
  • Yoshida H., Okabe Y., Kawane K., Fukuyama H., & Nagata S.
    Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA Nature Immunology, 6, 49-56, 2005