Immune Homeostasis
TEL +81-6-6879-4932
Overview
Homeostasis is the system to maintain regulated variables (body temperature, blood glucose, tissue size, and so on) within acceptable ranges. Immune system can be considered as a type of homeostatic mechanism in order to keep our body harmless. Our goal is to understand the mechanisms of tissue homeostasis and immune homeostasis as well as the mechanisms of diseases caused by the abnormality/exaggeration of homeostatic regulation.
Principal Investigator
Yasutaka Okabe Associate Professor
Research field
1. Mechanisms of Tissue-Resident Macrophage Diversity
2. Immune Systems of Body Cavity
3. Mechanisms of Airway Homeostasis
Education history
| 2000 | Waseda University, B.A. |
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| 2002 | Waseda University Graduate School, M.A. |
| 2006 | Osaka University Graduate School, Ph.D. |
Research and career history
| 2004 | Young Scientist Research Fellow, JAPAN Society for the Promotion of Science (-2006) |
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| 2006 | Post-doctoral fellow, Osaka University Graduate School (-2007) |
| 2007 | Post-doctoral fellow, Kyoto University Graduate School (-2008) |
| 2008 | Post-doctoral fellow, Yale University School of Medicine (-2012) |
| 2010 | Overseas Research Fellow, JAPAN Society for the Promotion of Science (-2012) |
| 2012 | Associate Research Scientist, Yale University School of Medicine (-2016) |
| 2016 | Program-Specific Associate Professor, Institute for Frontier Life and Medical Sciences, Kyoto University (-2020) |
| 2019 | PRESTO Researcher, JAPAN Science and Technology Agency |
| 2020 | Specially Appointed Associate Professor, IFReC, Osaka University |
Prize
| 2006 | Yamamura Award (Osaka Univesity) |
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| 2015 | Commendation for Young Scientists (Ministry of Education, Culture, Sports, Science and Technology, JAPAN) |
| 2016 | Kishimoto Fellow (Japanese Society for Immunology) |
Members
- Yasutaka Okabe Associate Professor
yokabeifrec.osaka-u.ac.jp - Noriko Shinjyo Postdoctoral fellow
- Haruna Kimura Technical Assistant
- Tomomi Yoshihara Technical Assistant
Achievements
Publications
- Okabe Y.
Molecular Control of the Identity of Tissue-Resident Macrophages International Immunology, 30, 485-491, 2018 - Okabe Y., & Medzhitov R.
Tissue Biology Perspective on Macrophages. Nature Immunology, 17, 9-17, 2016 - Okabe Y., & Medzhitov R.
Tissue-specific signals control reversible program of localization and functional polarization of macrophages, Cell, 157, 832-844, 2014 - Okabe Y., Sano T., & Nagata S.
Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature, 460, 520-524, 2009 - Okabe Y., Kawane K., & Nagata S.
IFN regulatory factor (IRF) 3/7-dependent and –independent gene induction by mammalian DNA that escapes degradation European Journal of Immunology, 38, 3150-3158, 2008 - Okabe Y., Kawane K., Akira S., Taniguchi T., & Nagata S.
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation The Journal of Experimental Medicine, 202, 1333-1339, 2005 - Yoshida H., Okabe Y., Kawane K., Fukuyama H., & Nagata S.
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA Nature Immunology, 6, 49-56, 2005