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Cutaneous Allergy and Host Defense

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Overview

In chronic inflammatory diseases such as atopic dermatitis (AD), which are not classified as infectious diseases, it is important to determine whether the detection of a specific pathogen is simply a result of the disease, or whether it is involved in the pathology/cause of the disease. We previously found that accessory gene regulatory (Agr) quorum sensing (QS) in Staphylococcus aureus is essential for skin adaptation of this pathogenic bacteria and Agr-QS-associated toxins induce skin inflammation in AD. Since the onset of AD in infancy is involved in the subsequent development of food allergies, asthma, etc., known as the allergic march, one important research goal is to elucidate the mutual mechanism between host immunity and microorganisms in the presymptomatic infantile phase of AD. We are also interested in the role of bacterial QS in the hospital adaptation of S. aureus. This develops the diagnostic and therapeutic platforms of this hospital-adapted S. aureus and overcomes MRSA outbreaks.

Fig.1

Principal Investigator

Yumi Matsuoka Professor

Research field

Cutaneous Allergy and Host Defense

Education history

2003 M.D., Yamanashi Medical University 
2009 Ph.D., Chiba University Graduate School of Medicine
2015 Board Certified Dermatologist, The Japanese Dermatological Association

Research and career history

2003 Resident, Department of Dermatology, Yamanashi University Hospital (-2005)
2005 Clinical Fellow, Department of Dermatology, Yamanashi University Hospital (-2006)
2006 Clinical Fellow, Department of Dermatology, Chiba University Hospital (-2009)
2009 Postdoctoral Fellow, Department of Pathology, University of Michigan Medical School, USA. Mentor: Gabriel Nunez (-2013)
2013 Research Fellow, General Foundation Japan Preventive Medicine Association (-2014)
2014 Assistant Professor, Department of Dermatology, Chiba University Graduate School of Medicine (-2017)
2018 Lecturer, Department of Dermatology, Chiba University Graduate School of Medicine (-2019)
2020 Specially Appointed Associate professor, Osaka University Immunology Frontier Research Center (-2021)
2022 Associate professor, Osaka University Immunology Frontier Research Center
2022- Professor, Osaka University Immunology Frontier Research Center

Members

  • Yumi Matsuoka Professor
    ymatsuokaderma.med.osaka-u.ac.jp

Achievements

Publications

  • Nakamura Y, Kambe N, Saito M, Nishikomori R, Kim YG, Murakami M, Núñez G, Matsue H.; Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med. 2009 ; 206(5):1037-46.
     
  • Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Núñez G.; Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity. 2012 ; 37(1):85-95.
     
  • Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G. Staphylococcus δ-toxin induces allergic skin disease by activating mast cells. Nature. 2013 ; 503(7476):397-401.
     
  • Nakagawa S, Matsumoto M, Katayama Y, Oguma R, Wakabayashi S, Nygaard T, Saijo S, Inohara N, Otto M, Matsue H, Núñez G, Nakamura Y. Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation. Cell Host Microbe. 2017 ; 22(5):667-677.
     
  • Baldry M, Nakamura Y, Nakagawa S, Frees D, Matsue H, Núñez G, Ingmer H. Application of an agr-specific anti-virulence Compound as Therapy for Staphylococcus Aureus-induced Inflammatory Skin Disease. J Infect Dis. 2018 ; 218(6):1009-1013.
     
  •  Miyachi H, Wakabayashi S, Sugihira T, Aoyama R, Saijo S, Koguchi-Yoshioka H, Fujimoto M, Núñez G, Matsue H, Nakamura Y. Keratinocyte IL-36 Receptor/MyD88 Signaling Mediates Malassezia-Induced IL-17-Dependent Skin Inflammation. J Infect Dis. 2021;223(10):1753-1765.
     
  • Nakamura Y, Takahashi H, Takaya A, Inoue Y, Katayama Y, Kusuya Y, Shoji T, Takada S, Nakagawa S, Oguma R, Saito N, Ozawa N, Nakano T, Yamaide F, Dissanayake E, Suzuki S, Villaruz A, Varadarajan S, Matsumoto M, Kobayashi T, Kono M, Sato Y, Akiyama M, Otto M, Matsue H, Núñez G, Shimojo N. Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development. Sci Transl Med. 2020 ; 12(551): eaay4068. doi: 10.1126/scitranslmed.aay4068.
     
  • Matsumoto M, Nakagawa S, Zhang L, Nakamura Y, Villaruz AE, Otto M, Wolz C, Inohara N, Núñez G. Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin. Cell Host Microbe. 2021 ;29(6):930-940.
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