The authors found Treg can render self-reactive human CD8+ T cells anergic (i.e., hypoproliferative and cytokine hypoproducing upon antigen restimulation) in vitro, likely by controlling the costimulatory function of antigen-presenting cells.

• Maeda･Nishikawa･Sakaguchi SCIENCE_20141219.pdf
• [Article ]Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals

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