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β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome (Hisashi ARASE in Blood)
The authors demonstrate that intact β2GPI, not peptide, forms a complex with HLA class II molecules. Strikingly, 100 of the 120 APS patients (83.3%) analyzed, including those whose antiphospholipid antibody titers were within normal range, possessed autoantibodies that recognize β2GPI/HLA class II complexes in the absence of phospholipids. In situ association between β2GPI and HLA class II was observed in placental tissues of APS patients but not in healthy controls.
Immunology Frontier Research Center (WPI-IFReC), Osaka University