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BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection (Takeda group, in JEM)
Kiyoshi Takeda's group (Mucosal Immunology) and others have revealed the regulation of immune response after Chagas disease causing Trypanosoma cruzi (T. cruzi) infection.
T. cruzi infection induces IL-23 production by host immune cells, and antigen-specific Th17 responses are then promoted. However, whether the IL-23-Th17 axis is controlled by IFN-γ-dependent mechanisms during T. cruzi infection remains unclear. In this study, they have demonstrated that IFN-γ-inducible BATF2 exerts its immunoregulatory function through the suppression of Il23a by interacting directly with c-JUN in innate immune cells, thereby preventing immunopathological Th17 responses during T. cruzi infection.
Article (External Link)
Kiyoshi Takeda（Mucosal Immunology）