News & Topics
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense (Yamamoto group, in Nature Immunology)
Masahiro Yamamoto's group (Immunoparasitology) and others have revealed a unique role of GABARAPs, in particular Gate-16, in interferon-γ (IFN-γ)-mediated antimicrobial response. The group showed that Gate-16 specifically associates with Arf1 to mediate uniform distribution of IFN-inducible GTPases, and that lack of Gate-16 reduces Arf1 activation, leading to formation of IFN-inducible GTPase-containing aggregates, hampering their function. Furthermore, mice lacking Gate-16 alone are susceptible to Toxoplasma. Thus, GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of IFN-inducible GTPases.
These results will help Gate-16 targeted strategy for the treatment of toxoplasmosis and alimentary intoxication caused by Toxoplasma and Salmonella.
Article (External Link)
Masahiro Yamamoto（Immunoparasitology ）