The research group of Hisashi Arase (Immunochemistry, IFReC/RIMD, Osaka University) and University of Oxford determined a structure of a RIFIN bound to LILRB1, and showed the RIFIN mimics the natural activating ligand of LILRB1, MHC class I, in its LILRB1-binding mode.

Fig.1 Mechanism of immune escape by P. falciparum (Saito et al. Nature 2017).

Fig. 2 Binding structure of LILRB1-binding RIFIN (L) and LILRB1-binding MHC I (R).

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Hisashi Arase (Immunochemistry)

+81-6-6879-8291
arasebiken.osaka-u.ac.jp
WPI Osaka University Immunology Frontier Research Center