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Unique tissue-resident memory CD4+ T cells in Crohn's disease (Takeda G, in PNAS)


Crohn's disease causes chronic inflammation in the gastrointestinal tract, and its onset is attributed to an excessive immune response of CD4-positive helper T cells.
Mari Murakami (Graduate School of Medicine, Osaka University), Kiyoshi Takeda (Director of IFReC), and the research group identified tissue-resident memory T cells that increase in the intestinal tract of patients with Crohn's disease and exacerbate the condition.

In the gut of Crohn's disease patients, inflammatory CD4+ CD103+ CCR5+CD161+ tissue-resident memory T cells (Pathogenic TRM) localize adjacent to the epithelial cells. These cells are stimulated by cytokines which are abundant in the gut of Crohn's disease patients, and secrete inflammatory factors that damage the epithelial cells and exacerbate the disease state.

Kiyoshi Takeda Lab.

Mucosal Immunology