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Unique tissue-resident memory CD4+ T cells in Crohn's disease (Takeda G, in PNAS)
Crohn's disease causes chronic inflammation in the gastrointestinal tract, and its onset is attributed to an excessive immune response of CD4-positive helper T cells.
Mari Murakami (Graduate School of Medicine, Osaka University), Kiyoshi Takeda (Director of IFReC), and the research group identified tissue-resident memory T cells that increase in the intestinal tract of patients with Crohn's disease and exacerbate the condition.
Kiyoshi Takeda Lab.