In contrast to a second dose of the SARS-CoV-2 mRNA vaccine, a third dose elicits potent neutralizing activity against the Omicron variant. Takeshi Inoe, Tomohiro Kurosaki (Lymphocyte Differentiation, IFReC), and the research group showed that pre-generated antibodies modulate the selection of GC and subsequent memory B cells after the second vaccine dose, accumulating more Omicronreactive memory B cells over time, which contributes to the generation of Omicron-neutralizing antibodies elicited by the third vaccine dose.

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Kurosaki Lab

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kurosakiifrec.osaka-u.ac.jp

Lymphocyte Differentiation