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Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity (Kumanogoh & Y. Okada G, in Nat Gen.)
Atsushi Kumanogoh (Graduate School of Medicine, Osaka University/IFReC), Yukinori Okada (Graduate School of Medicine, Osaka University/IFReC/RIKEN/ Graduate School of Medicine, University of Tokyo) and the research group found that CD14+CD16++ monocytes, a rare subset among monocytes, are involved in COVID-19 severity. Further, COVID-19 severity-associated genes such as IFNAR2, have specific function mainly in monocytes and dendritic cells.
Yukinori Okada Laboratory