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A surprising way to disrupt sleep (A. Millius et al., in PNAS)


Circadian rhythms, the internal biological clocks that regulate our daily activities, are essential for maintaining health and well-being. The research group of Arthur Millius (RIKEN/present: IFReC), Kazuhiko Maeda (Host Defense, IFReC), Daron Standley (System Immunology, IFReC), and Hiroki Ueda (RIKEN) showed how translation and post-transcriptional processes influence the body's internal clock and its impact on sleep patterns.

Figure PNAS

Disruption of the Per2 uORF disrupts the amplitude of circadian rhythms (left) and reduces sleep in mice (right). License: CC BY 4.0