Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Dr. Chao-Yuan Tsai and the researchers of Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells. Mice that lacked the longer isoform, RUBCN130, produced more memory B cells in a way that relied on autophagy. These findings provide further insight into the role of Rubicon in autophagy.