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Targeting autophagy to enhance memory immune responses (Tsai et al., in Sci Signal.)


Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Dr. Chao-Yuan Tsai and the researchers of Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells. Mice that lacked the longer isoform, RUBCN130, produced more memory B cells in a way that relied on autophagy. These findings provide further insight into the role of Rubicon in autophagy.

Tsai Sci Signal_figure_ENG