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STIM-mediated calcium influx regulates maintenance and selection of GC B cells (Baba-Kurosaki G, in JEM)
Germinal centers (GCs) are specialized microenvironments where antigen-specific B cells undergo antibody affinity maturation and clonal expansion. However, the requirements of BCR signaling in GC B cells remain poorly understood. Yoshihiro Baba (Kyushu University), Tomohiro Kurosaki (Lymphocyte Differentiation, IFReC) and the research group showed that stromal interacting molecule (STIM)-deficient B cells have reduced B cell competitiveness compared to wild-type B cells during GC responses.
(online publishing in Journal of Experimental Medicine on October 30, 2023)