Interleukin (IL)-6, an essential indicator of cytokine release syndromes (CRS), regulates vascular homeostasis and inflammation. Inhibition of IL-6 receptor (IL-6R) signaling is beneficial for various CRS; however, it is limited by adverse effects related to poor understanding of mechanisms involved. Tadamitsu Kishimoto and Sujin Kang, and their research group discovered that hypoxia-inducible factor (HIF1) α signaling is activated by IL-6R trans-signaling in endothelial cells, which promotes vascular inflammatory responses and endothelial permeability by glycolysis.
(online publishing in Proceedings of the National Academy of Sciences USA (PNAS) on January 2, 2024)

Contact

Kang-Kishimoto Lab

kishimotoifrec.osaka-u.ac.jp

Immune Regulation