The complex mechanism for GC B cell selection during affinity maturation process is not fully understood. The research group of Takeshi Inoue (The University of Tokyo and Osaka University), Masato Okada (CAMaD, Osaka University), and Tomohiro Kurosaki (RIKEN and WPI-IFReC, Osaka University) examined the role of B cell receptor signaling during this process, and discovered that Csk (a tyrosine kinase attenuating BCR signaling) is required for GC maintenance and efficient antibody maturation. 
(online publishing in Journal of Experimental Medicine on May 16, 2024)

Contact

Tomohiro Kurosaki

kurosakiifrec.osaka-u.ac.jp

Lymphocyte Differentiation