Regulated neural-metabolic-inflammatory responses are essential for maintaining physiological homeostasis. However, the molecular machinery that coordinates neural, metabolic, and inflammatory responses is largely unknown.

Using genome-wide approaches, the research group of Sujin Kang (Immune Regulation, WPI-IFReC) and Atsushi Kumanogoh  (Graduate School of Medicine/WPI-IFReC) showed that semaphorin 6D (SEMA6D) coordinates anxiogenic, metabolic, and inflammatory outputs from the amygdala by maintaining synaptic homeostasis. 

(online publishing in Neuron on July 12, 2024)

Contact

Prof. Atsushi Kumanogoh

kumanogoimed3.med.osaka-u.ac.jp

Immunopathology