Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited.

The research group of Yukinori Okada (Graduate School of Medicine, Osaka University/WPI-IFReC/The University of Tokyo/RIKEN) analyzed whole-genome sequencing datasets of 6,321 individuals, including patients with five autoimmune diseases and coronavirus disease 2019 (COVID-19), or healthy controls. They showed Participants with eHHV-6B had higher risks of SLE and PAP. eHHV-6B-positivity and high SLE disease activity index scores had strong correlations.
(online publishing in Nature Genetics on Jan. 3, 2025)

Contact

Prof. Yukinori Okada

yokadasg.med.osaka-u.ac.jp

Statistical Immunology