Crohn's disease is an intractable　disorder characterized by chronic inflammation in the digestive tract. Tissue-resident memory T cells (TRM), which persist in long-term in the intestinal mucosa, have been implicated in disease pathogenesis, but it has not been clear how these cells are induced.

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ IFReC/ CiDER, The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.
(online publication in JEM on Sep. 4, 2025)

Contact

Kiyoshi Takeda Lab.

ktakedaongene.med.osaka-u.ac.jp

Mucosal Immunology