Immunopathology

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Semaphorins are originally identified as axonal guidance factors in the developing nervous system in 1990s. Cumulative evidence suggests that semaphorins also play important roles in the other systems, including organogenesis, vascularization, angiogenesis and the progression of cancers. In 2000, our research groups have identified a class IV semaphorin, CD100/Sema4D, as an immune-regulatory molecule expressed on immune cells. To date, it becomes clear that some other semaphorins (Sema3A, Sema4A, Sema4B, Sema4G, Sema4F, Sema6A, Sema6B, Sema6D, Sema7A) are also expressed in the immune system and play non-redundant roles in immune responses. These semaphorins are now called as ‘immune semaphorins’ (Fig.1). Immune semaphorins are involved in various phases of immune responses including activation phase, differentiation phase and effecter phase (Fig.2). We work on the molecular mechanisms underlying regulation of immune responses by immune semaphorins.

Fig.1 Representative Immune Semaphorins

Fig.2 Involvement of semaphorins in various phases of immune responses

Principal Investigator

Atsushi Kumanogoh Professor

Research field:Immunology
+81-6-6879-3833
kumanogoimed3.med.osaka-u.ac.jp
Education history
1991Graduate from Medical School of Osaka University

Members

TanakaToshio Professor
ttanakimed3.med.osaka-u.ac.jp
Toshihiko Toyofuku Professor
toyofukuimed3.med.osaka-u.ac.jp
Oka Yoshihiro Professor
yoshiimed3.med.osaka-u.ac.jp
Narazaki Masashi Associate Professor
mnarazakiimed3.med.osaka-u.ac.jp
Kijima Takashi Associate Professor
tkijimaimed3.med.osaka-u.ac.jp
Hyota Takamatsu Associate Professor
thyotaimed3.med.osaka-u.ac.jp
Sujin Kang Associate Professor
kangimed3.med.osaka-u.ac.jp
Tatsusada Okuno Associate Professor
okunoneurol.med.osaka-u.ac.jp
Satoshi Nojima Associate Professor
s_nojimaneurol.med.osaka-u.ac.jp
Koyama Shohei Associate Professor
koyamaimed3.med.osaka-u.ac.jp
Morita Takayoshi Associate Professor
t-moritaimed3.med.osaka-u.ac.jp
 
 

Journal

Schulz E et al. Nature Commun. 5:5191. 2014.
Kumanogoh A and Kikutani H. Nature Rev Immunol. 13:802-14. 2013.
Nojima S et al. Nature Commun. 4:1406. 2013.
Hayashi T et al. Nature 485:69-74, 2012.
Nogi T et al. Nature 467:1123-7, 2010.
Takamatsu et al. Nature Immunology 11, 594-600, 2010.
Suzuki et al. Nature Immunology 9, 17-23, 2008.
Suzuki K, Kumanogoh A (*corresponding author) et al. Nature 446, 680-684, 2007.
Takegahara, N, Kumanogoh A (*corresponding author) et al. Nat Cell Biol. 8, 615-622, 2006.
Kumanogoh A. et al. Immunity 22, 305-16, 2005.
Kikutani H. and Kumanogoh A. Nat. Rev. Immunol. 3, 159-167, 2003.
Kumanogoh A. et al. Nature 419, 629-633, 2002.