Immune Response Dynamics

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It has long been proposed that various aspects of immune responses are influenced by nervous system activity. However, little is known about how the inputs from the nervous system control the immune system. Therefore, we have been studying the cellular and molecular basis for the neural regulation of immunity. We have demonstrated that adrenergic nerves control lymphocyte trafficking through lymph nodes. Neural inputs to lymphocyte β2-adrenergic receptors enhance signals through chemokine receptors CCR7 and CXCR4, and consequently inhibit lymphocyte egress from lymph nodes (J. Exp. Med. 2014). Moreover, this mechanism contributes to diurnal variations of adaptive immune responses (J. Exp. Med. 2016). At this moment, however, the molecular basis for the crosstalk between β2-adrenergic receptors and chemokine receptors is unclear. Additionally, the real picture of the interactions between adrenergic nerves and lymphocytes remains to be visualized. We are going to address these questions in our future studies, and move forward to comprehensive understanding of immune regulation by the nervous system.

Figure. Adrenergic control of lymphocyte dynamics

Principal Investigator

Kazuhiro Suzuki Professor

Research field: Neural regulation of adaptive immunity
+81-6-6879-4939
ksuzuki atmark ifrec.osaka-u.ac.jp
Education history
2007.9 PhD, Graduate School of Medicine, Osaka University
2003.3 2003.3 MD, Medical School of Osaka University
1998.3 BSc, School of Science, The University of Tokyo
Research and career history
2017.4- Professor, IFReC, Osaka University
2011.10-2015.3 PRESTO researcher, JST
2011.4-2017.3 Associate professor, IFReC, Osaka University
2007.10-2011.3 Postdoctoral fellow, University of California, San Francisco, USA
2006.4-2007.9 JSPS fellow (DC2)
2003.4-2004.3 Resident in internal medicine, Osaka University Hospital

Members

Akiko Nakai Assistant Professor
anakai atmark ifrec.osaka-u.ac.jp
Fumika Furuta Laboratory Technician
ffuruta atmark ifrec.osaka-u.ac.jp
Yoshiko Ota Laboratory Technician
yota atmark ifrec.osaka-u.ac.jp
 
 

Publications

Suzuki, K., Hayano, Y., Nakai, A., Furuta, F. and Noda, M. Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes. J. Exp. Med. 213: 2567-2574, 2016.
Nakai, A., Hayano, Y., Furuta, F., Noda, M. and Suzuki, K. Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors. J. Exp. Med. 211: 2583-2598, 2014.
Green, J.A., Suzuki, K., Cho, B., Willison, D., Palmer, D., Allen, C.D.C., Schmidt, T.H., Xu, Y., Proia, R., Coughlin, S.R. and Cyster, J.G. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat. Immunol. 12: 672-680, 2011.
Suzuki, K., Grigorova, I., Phan, T.G., Kelly, L.M. and Cyster, J.G. Visualizing B cell capture of cognate antigen from follicular dendritic cells. J. Exp. Med. 206: 1485-1493, 2009
Suzuki, K., Kumanogoh, A. and Kikutani, H. Semaphorins and their receptors in immune cell interactions. Nat. Immunol. 9: 17-23, 2008.
Suzuki, K., Okuno, T., Yamamoto, M., Pasterkamp, R.J., Takegahara, N., Takamatsu, H., Kitao, T., Takagi, J., Rennert, P.D., Kolodkin, A.L., Kumanogoh, A. and Kikutani, H. Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin. Nature 446: 680-684, 2007.

Awards

2016 Medical Research Encouragement Prize
(The Japan Medical Association)
2016 Astellas award for the best biomedical research
(The Astellas Foundation for Research on Metabolic Disorders)
2016 Astellas award for the outstanding presentation
(The Astellas Foundation for Research on Metabolic Disorders)
2012 Young Investigator Award
(The Japanese Society of Immunology)
2009 Inoue Research Award for Young Scientists
(The Inoue Foundation for Science)
2008 Long-term Fellowship
(Human Frontier Science Program)
2008 The Yamamura Prize
(Graduate School of Medicine, Osaka University)
2003 The Yamamura Prize
(Medical School of Osaka University)