Immunoparasitology

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Principal Investigator

Masahiro Yamamoto Professor

+81-6-6879-8333
myamamoto atmark biken.osaka-u.ac.jp
Education history

2001Graduated from undergraduate course of Faculty of Science, The University of Tokyo
2003 Graduated from master course of graduate school of medicine, Osaka University
2006 Graduated from Ph.D course of graduate school of medicine, Osaka University

Research and career history

2003RIKEN, the Junior Research Associate
2004-2006Research fellow, the Japan Society for the Promotion of Science
2006Post doctoral fellow, Research Institute for Microbial Diseases, Osaka University
2006Assistant Professor, Department of Immune regulation, Graduate School of Medicine, Osaka University
2010-2011Associate Professor, Department of Immune regulation, Graduate School of Medicine, Osaka University
2012-2013Associate Professor, Department of Immunoparasitology Research Institute for Microbial Diseases, Osaka University
2012-2013Associate Professor, Department of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University
2012-2013 Professor, Department of Immunoparasitology Research Institute for Microbial Diseases, Osaka University
2012-2013 Professor, Department of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University

Members

Myoung Ho Jang Guest Associate Professor

Miwa Sasai Assistant Professor
m-sasai atmark biken.osaka-u.ac.jp
Ma Jisu Assistant Professor
majisu atmark biken.osaka-u.ac.jp
Mari Enomoto Laboratory Technician
enomoto-m atmark ifrec.osaka-u.ac.jp
 
 

Publications

Ohshima J, Lee Y, Sasai M, Saitoh T, Ma JS, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M . Role of the mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii. J Immunol. (2014) 192: 3328-3335.
Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DS, Soldati-Favre D, Horie K, Takeda J, Takeda K. A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity (2012) 37:302-313.
Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K. ATF6b is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J Exp Med. (2011) 208:1533-1546.
Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K. A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.J Exp Med. (2009) 206: 2747-2760.
Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med. (2007) 204:2233-9.
Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S. Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling. J Immunol. (2006) 177:7520-4.
Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol. (2006) 7:962-70.
Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkBz. Nature. (2004) 430:218-22.
Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. (2003) 4:1144-50.
Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway. Science. (2003) 301:640-3.
Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S. Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-b Promoter in the Toll-Like Receptor Signaling. J Immunol. (2002) 169:6668-72.
Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature.(2002) 420:324-329.

Prize

2006.3 Yamamura Prize
2007.11 JSI Young Investigator Award
2011.4 The Commendation for Science and Technology by the MEXT (The Young Scientists' Prize)