Biochemistry & Immunology

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Principal Investigator

Shigekazu Nagata Professor

+81-6-6879-4953
snagata atmark ifrec.osaka-u.ac.jp
Education history
1968-72Undergraduate Student Faculty of Science, University of Tokyo
1972-77Graduate Student Department of Chemistry, Institute of Medical Science, University of Tokyo
Research and career history
1977-77Research Associate Department of Chemistry, Institute of Medical Science, University of Tokyo
1977-81Post-Doctral Fellow Institute of Molecular Biology, University of Zurich
1982-87Assistant Professor at the Institute of Medical Science, University of Tokyo
1987-98Head, Department of Molecular Biology, Osaka Bioscience Institute
1995-07Professor, Department of Genetics, Graduate School of Medicine, Osaka University
2002-07Professor, Integrated Biology Laboratories, Graduate School of Frontier Bioscience, Osaka University
2007-15Professor, Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
2015-Professor, Immunology Frontier Research Center (IFRec), Osaka University

Members

Jun Suzuki Guest Professor
jsuzuki atmark ifrec.osaka-u.ac.jp
Katsumori Segawa Associate Professor
ksegawa atmark ifrec.osaka-u.ac.jp
Yuichi Yanagihashi Researcher
yyanagihashi atmark ifrec.osaka-u.ac.jp
Sayuri Gyobu Researcher
sgyobu atmark ifrec.osaka-u.ac.jp
Chihiro Nishi Researcher
cnishi atmark ifrec.osaka-u.ac.jp
 
 

Publications

Nagata S, Taira H, Hall A, Johnsrud L, Streuli M, Ecsodi J, Boll W, Cantell K and Weissmann C (1980) Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature 284: 316-320.
Nagata S, Mantei N and Weissmann C (1980) The structure of one of the eight or more distinct chromosomal genes for human interferon-. Nature 287: 401-408.
Streuli M, Nagata S and Weissmann C (1980) At least three human type a interferons: structure of 2. Science 209: 1343-1347.
Taniguchi T, Mantei N, Schwarzstein M, Nagata S, Muramatsu M and Weissmann C (1980) Human leukocyte and fibroblast interferons are structurally related. Nature 285: 547-549.
Nagata S, Tsuchiya M, Asano S, Kaziro Y, Yamazaki T, Yamamoto O, Hirata Y, Kubota N, Oheda M, Nomura H and Ono M (1986) Molecular cloning and expression of cDNA for human granuloctye colony-stimulating factor. Nature 319: 415-418.
Fukunaga R, Ishizaka-Ikeda E, Seto Y and Nagata S (1990) Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell 61: 341-350.
Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y and Nagata S (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233-243.
Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA and Nagata S (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314-317.
Fukunaga R, Ishizaka-Ikeda E and Nagata S (1993) Growth and differentiation signals mediated by two distinct regions in the cytoplasmic domain of G-CSF receptor. Cell 74: 1079-1087.
Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T and Nagata S (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364: 806-809.
Suda T, Takahashi T, Golstein P and Nagata S (1993) Molecular cloning and expression of the Fas ligand: a novel member of the tumor necrosis factor family. Cell 75: 1169-1178.
Kägi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S, Hengartner H and Golstein P (1994) Fas and perforin pathway as major mechanisms of T cell-mediated cytotoxicity. Science 265: 528-530.
Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T and Nagata S (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969-976.
Enari M, Hug H and Nagata S (1995) Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375: 78-81.
Enari M, Talanian RV, Wong WW and Nagata S (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380: 723-726.
Tanaka M, Suda T, Haze K, Nakamura N, Sato K, Kimura F, Motoyoshi K, Mizuki M, Tagawa S, Ohga S, Hatake K, Drummond A and Nagata S (1996) Fas ligand in human serum. Nat. Med. 2: 317-322.
Kondo T, Suda T, Fukuyama H, Adachi M and Nagata S (1997) Essential roles of the Fas ligand in the development of hepatitis. Nat. Med. 3: 409-413.
Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A and Nagata S (1998) A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD. Nature 391: 43-50.
Sakahira H, Enari M and Nagata S (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391: 96-99.
Tanaka M, Itai T, Adachi M and Nagata S (1998) Down-regulation of Fas ligand by shedding. Nat. Med. 4: 31-36.
Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, Uchiyama Y and Nagata S (2001) Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science 292: 1546-1549.
Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A and Nagata S (2002) Identification of a factor that links apoptotic cells to phagocytes. Nature 417: 182-187.
Kawane K, Fukuyama H, Yoshida H, Nagase H, Ohsawa Y, Uchiyama Y, Iida T, Okada K and Nagata S (2003) Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat. Immunol 4: 138-144.
Nishimoto S, Kawane K, Watanabe-Fukunaga R, Fukuyama H, Ohsawa Y, Uchiyama Y, Hashida N, Ohguro N, Tano Y, Morimoto T, Fukuda Y, and Nagata S (2003). Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature 424: 1071-1074.
Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, and Nagata S (2004). Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304: 1147-1150.
Yoshida H, Okabe Y, Kawane K, Fukuyama H, and Nagata S (2005). Lethal anemia caused by interferon- produced in mouse embryos carrying undigested DNA. Nat. Immunol 6: 49-56
Yoshida H, Kawane K, Koike M, Mori Y, Uchiyama Y, and Nagata S (2005). Phosphatidylserine- dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 437: 754-758.
Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y, Yoshikawa H and Nagata S (2006) Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443: 998-1002.
Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., and Nagata, S. (2007) Identification of Tim-4 as a phosphatidylserine receptor. Nature 450: 435-439.
Okabe, Y., Sano, T. and Nagata, S. (2009) Regulation of the innate immune response by threonine phosphatase of Eyes absent. Nature 460: 520-524
Suzuki, J., Umeda, M., Sims JP. and Nagata, S. (2010) Calcium-dependent phospholipid scrambling by TMEM16F. Nature 468: 834-838.
Suzuki, J., Denning, DP., Imanishi, E., Horvitz, HR. and Nagata, S. (2013) Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 341: 403-406.
Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T., Matsuda, F., and Nagata, S. (2014) Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science 344, 1164-1168

Review

Nagata S and Golstein P (1995) The Fas death factor. Science 267: 1449-1456.
Nagata S (1997) Apoptosis by death factor. (Review) Cell 88: 355-365.
Nagata S (1999). Fas ligand-induced apoptosis. Annu Rev Genetics 33: 29-55.
Nagata S (2005). DNA degradation in development and programmed cell death. Annu Rev Immunol 23: 853-875.
Nagata, S., Hanayama, R. and Kawane, K. (2010) Autoimmunity and the Clearance of Dead Cells. Cell 140: 619-630.

Prize

1994.11 Emil Adolf von Behring Prize (Philipps-Universität Marburg, Germany)
1995.10Robert Koch Award (Koch Foundation, Germany)
1996.11Boehring-Kitasato Prize (Tokyo)
1997.1Le Prix Antoine Lacassagne (French Cancer League, France)
1998.1Asahi Prize (Tokyo)
1998.2Takmatsu Cancer Award (Tokyo)
2000.6Japan Academy Prize, Imperial Prize (Japan)
2001.11Person of Cultural Merits (Japan)
2004.6 International Cell Death Society Prize (Maynooth, Ireland)
2011.1 The member of The Japan Academy (Japan)
2012.4Honorary Doctorate (Univ. of Zurich, Switzerland)
2012.9 Yoshida Prize (Japanese Cancer Association, Japan)
2012.12 Debrecen Award (Debrecen University, Hungary)
2013.6 Kyoto University Shi-Shi Award (Kyoto University, Japan)
2013.11Keio Medical Science Prize (Keio Univ./Japan)
2015.4 Foreign Associate of National Academy of Sciences, USA