Significant achievements

2014.12.19

Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4 (Shimon SAKAGUCHI in Immunity)

The authors found Treg cells directly inhibited, via CTLA-4, B cell expression of CD80 and CD86, which was essential for Tfh cell formation.

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Shimon SAKAGUCHI

Shimon SAKAGUCHI（Experimental Immunology）

Tel 06-6879-4461 Mail shimonatmarkifrec.osaka-u.ac.jp

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