Kiyoshi Takeda's group (Mucosal Immunology) and others have revealed the regulation of immune response after Chagas disease causing Trypanosoma cruzi (T. cruzi) infection.
T. cruzi infection induces IL-23 production by host immune cells, and antigen-specific Th17 responses are then promoted. However, whether the IL-23-Th17 axis is controlled by IFN-γ-dependent mechanisms during T. cruzi infection remains unclear. In this study, they have demonstrated that IFN-γ-inducible BATF2 exerts its immunoregulatory function through the suppression of Il23a by interacting directly with c-JUN in innate immune cells, thereby preventing immunopathological Th17 responses during T. cruzi infection.

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Contact:

Kiyoshi Takeda（Mucosal Immunology）

06-6879-3980 ktakedaongene.med.osaka-u.ac.jp

Immunology Frontier Research Center (WPI-IFReC), Osaka University (WPI-IFReC)