News & Topics

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome (Takamatsu-Kumanogoh G, in EMBO J.)

An activin A-producing osteoclastogenic fibroblast subset inducing bone destruction in cholesteatoma (M Ishii G, in Nat Commun.)

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity (Yamamoto G, in Cell Rep.)

The double face of RNase as a treatment for systemic autoimmune diseases (Arase G, in JCI Insight)

How does M. leprae disrupt macrophages? (Yamasaki G, in ACS Cent Sci.)

A cancer-associated METTL14 mutation affects tumor growth (Kumanogoh G, in Cell Rep.)

Shared genetic backgrounds underlying carcinogenesis (Y Okada G, in Nat Commun)

Host genetics uncover IFN-γ-dependent Toxoplasma genes in in vivo CRISPR screens (Yamamoto G, in Cell Rep.)

Semaphorin 4A improves the efficacy of anti-PD-1 antibody (Kumanogoh G, in Sci Adv.)

Age-related B-cell senescence causes dysbiosis of gut microbiota (Hara G, in Nat Cell Biol.)

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases (Sakuragi & Nagata, in Nat Rev Mol Cel Biol)

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity (Kumanogoh & Y. Okada G, in Nat Gen.)

Celastrol improves the pathology of autoimmune disease by suppressing the COMMD3/8 complex (Suzuki G, in Sci Immunol)

Distinct myeloid cells temporally associated with COVID-19 vaccination (Okuzaki G, in Front Immunol.)

Timing matters for dendritic cell signaling (Yamasaki G, in Sci Signal.)

Aldh1a2+ fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots. (Okabe G, in JEM)

Why men are at higher risk from COVID-19 (WIng G, in PNAS)

Gaucher disease is caused by the activation of microglia (Yamasaki G, in Immunity)

Activin A-producing alveolar macrophage supports the progression of lung cell carcinoma (M Ishii G, in Nat Commun.)

Antibody feedback contributes to the development of Omicron-reactive memory B cells (Inoue-Kurosaki G, in JEM)

Unique tissue-resident memory CD4+ T cells in Crohn's disease (Takeda G, in PNAS)

Persistence of COVID-19 vaccine efficacy in patients with immune diseases (Kumanogoh G, in Lancet Reg Health West Pac.)

Tracking plasma cell survival (Ise and Kurosaki G, in JEM)

MACROH2A1 was identified as a biomarker associated with refractory COVID‑19 (Takeda and Kumanogoh G, in Inflamm Regen.)

The lysosomal Ragulator complex activates NLRP3 inflammasome (Kumanogoh G, in EMBO J.)

Autoimmune range of TCR signaling (Sakaguchi G, in JEM)

The intestinal microflora and viral flora of the Japanese population were characterized (Y Okada G, in Cell Genomics).

Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells (Kumanogoh G, in JCI Insight)

How myasthenia gravis develops in thymoma patients? (Ohkura & Sakaguchi G, in Nat Commun.)

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component (Y Okada G, in Ann Rheum Dis.)