News & Topics

STIM-mediated calcium influx regulates maintenance and selection of GC B cells (Baba-Kurosaki G, in JEM)

Immunological and clinical heterogeneity across autoimmune rheumatic diseases (Okada G, in ARD)

Two distinct phenotypes of newly-onset microscopic polyangiitis revealed by single-cell multi-omics analysis (Kumanogoh G, in Nat Commun.)

Targeting autophagy to enhance memory immune responses (Tsai et al., in Sci Signal.)

A surprising way to disrupt sleep (A. Millius et al., in PNAS)

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome (Takamatsu-Kumanogoh G, in EMBO J.)

An activin A-producing osteoclastogenic fibroblast subset inducing bone destruction in cholesteatoma (M Ishii G, in Nat Commun.)

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity (Yamamoto G, in Cell Rep.)

The double face of RNase as a treatment for systemic autoimmune diseases (Arase G, in JCI Insight)

How does M. leprae disrupt macrophages? (Yamasaki G, in ACS Cent Sci.)

A cancer-associated METTL14 mutation affects tumor growth (Kumanogoh G, in Cell Rep.)

Shared genetic backgrounds underlying carcinogenesis (Y Okada G, in Nat Commun)

Host genetics uncover IFN-γ-dependent Toxoplasma genes in in vivo CRISPR screens (Yamamoto G, in Cell Rep.)

Semaphorin 4A improves the efficacy of anti-PD-1 antibody (Kumanogoh G, in Sci Adv.)

Age-related B-cell senescence causes dysbiosis of gut microbiota (Hara G, in Nat Cell Biol.)

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases (Sakuragi & Nagata, in Nat Rev Mol Cel Biol)

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity (Kumanogoh & Y. Okada G, in Nat Gen.)

Celastrol improves the pathology of autoimmune disease by suppressing the COMMD3/8 complex (Suzuki G, in Sci Immunol)

Distinct myeloid cells temporally associated with COVID-19 vaccination (Okuzaki G, in Front Immunol.)

Timing matters for dendritic cell signaling (Yamasaki G, in Sci Signal.)

Aldh1a2+ fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots. (Okabe G, in JEM)

Why men are at higher risk from COVID-19 (WIng G, in PNAS)

Gaucher disease is caused by the activation of microglia (Yamasaki G, in Immunity)

Activin A-producing alveolar macrophage supports the progression of lung cell carcinoma (M Ishii G, in Nat Commun.)

Antibody feedback contributes to the development of Omicron-reactive memory B cells (Inoue-Kurosaki G, in JEM)

Unique tissue-resident memory CD4+ T cells in Crohn's disease (Takeda G, in PNAS)

Persistence of COVID-19 vaccine efficacy in patients with immune diseases (Kumanogoh G, in Lancet Reg Health West Pac.)

Tracking plasma cell survival (Ise and Kurosaki G, in JEM)

MACROH2A1 was identified as a biomarker associated with refractory COVID‑19 (Takeda and Kumanogoh G, in Inflamm Regen.)

The lysosomal Ragulator complex activates NLRP3 inflammasome (Kumanogoh G, in EMBO J.)