News & Topics
Research
2020.06.23
Tet2 and Tet3 in B cells repress CD86 and prevent autoimmunity (Kurosaki G, in Nat Immunol)
PRESS RELEASE
Wataru Ise, Tomohiro Kurosaki (Lymphocyte Differentiation, IFReC), Shinya Tanaka, Yoshihiro Baba (Kyushu University) and their research group reported that deficiency of ten-eleven translocation (Tet) DNA demethylase family members, Tet2 and Tet3, in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease.
Tet-mediated B cell tolerance
Tet2/3-deficient B cells are activated by self-antigen and express exaggerated amount of CD86.
Then those B cells stimulate autoreactive CD4+ T cells, resulting in autoimmune response.
Commentary(PDF)
Article (External Link)
Contact:
Tomohiro Kurosaki(Lymphocyte Differentiation)
+81-6-6879-4456
kurosakiifrec.osaka-u.ac.jp