News & Topics
Research
2020.08.24
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome (Kishimoto G, in PNAS)
PRESS RELEASE
Cytokine release syndrome (CRS) is a life-threatening complication induced by hyperinflammatory responses.
Sujin Kang, Tadamitsu Kishimoto (Immune Regulation, IFReC) and the research group found that interleukin (IL)-6 signaling plays a crucial role in endothelial cell dysfunction during bacterial and viral CRS.
Figure: How Actemra© suppresses inflammationIL-6 in blood promotes thrombus formation via PAI-1. By suppressing IL-6, Actemra prevents severity of the pneumonia due to cytokine storm.
Commentary (PDF)
Article (External Link)
Contact:
Tadamitsu Kishimoto(Immune Regulation)
+81-6-6879-4956
kishimoto@ifrec.osaka-u.ac.jp