主な論文
Temizoz B, Kuroda E, Ohata K, Jonai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ*. TLR9 and STING agonists synergistically induce innate and adaptive type II IFN. Eur J Immunol. 2015. 45(4) 1159?1169
Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley DM, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ* Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen. J Immunol. 2015 194(6):2673-82.
Koo CX, Kobiyama K, Shen YJ, LeBert N, Ahmad S, Khatoo M, Aoshi T, Gasser S, Ishii KJ*. RNA Polymerase III Regulates Cytosolic RNA:DNA Hybrids and Intracellular MicroRNA Expression. J Biol Chem. 2015. 290(12):7463-73
Onishi M, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Coban C, Ishii KJ* Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets Vaccine 2014 32(25):3004-9.
Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ*. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci U S A. 2014 111(8):3086-91. (Direct submission)
Kobiyama K, Kawashima A, Jounai N, Takeshita F, Ishii KJ, Ito T, Suzuki K. Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage. Front Genet. 2013 4:91.
Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama K, Dessailly BH, Kuroda E, Akira S, Mizuguchi K, Coban C, Ishii KJ*. The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant. PLoS One. 2013;8(3):e60038.
Kuroda E, Coban C, Ishii KJ* Particulate adjuvant and innate immunity:past achievements, present findings and future prospects. Int. Rev. Immunol. 2013 2013;32(2):209-20
Jounai N, Kobiyama K, Takeshita F, Ishii KJ*. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol. 2012 2 (168) 1-13.
Tetsutani K, Ishii KJ*. Adjuvants in influenza vaccines. Vaccine. 2012 30(52):7658-61.
Desmet CJ, Ishii KJ*. Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol. 2012 12(7):479-91.
Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ*, Bureau F*, Desmet CJ*. DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med. 2011 17(8):996-1002.
Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S*, Ishii KJ*. Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Sci Transl Med. 2010 2(25):25ra24.
Koyama S, Coban C, Aoshi T, Horii T, Akira S, Ishii KJ*. “Innate immune control of nucleic acid-based vaccine immunogenicity.” Expert Rev Vaccines. 2009 8(8):1099-107.
Ishii KJ*, Akira S*. “Potential link between the immune system and metabolism of nucleic acids.” Curr Opin Immunol. 2008 20(5):524-9.
Takeshita F, Ishii KJ*. “Intracellular DNA sensors in immunity.” Curr Opin Immunol. 2008 20(4):383-8
Ishii KJ*, Koyama S, Nakagawa A, Coban C, Akira S. “Host innate immune receptors and beyond: making sense of microbial infections.” Cell Host Microbe. 2008 3(6):352-63.
Coban C, Koyama S, Takeshita F, Akira S, Ishii KJ*. “Molecular and cellular mechanisms of DNA vaccines.” Hum Vaccin. 2008 4(6).
Ishii KJ*, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S*. “TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.” Nature. 2008 451(7179):725-9.
Ishii KJ*, Akira S. “Toll or Toll-Free Adjuvant Path Toward the Optimal Vaccine Development.” J Clin Immunol. 2007 27(4):363-71.
Ishii KJ, Uematsu S, Akira S. “’Toll' gates for future immunotherapy.” Curr Pharm Des. 2006;12(32):4135-42.
Ishii KJ, Akira S. “Innate immune recognition of, and regulation by, DNA.” Trends Immunol. 2006 27(11):525-32.
Ishii KJ, Coban C, Akira S. “Manifold Mechanisms of Toll-Like Receptor-Ligand recognition.” J Clin Immunol. 2005 25(6):511-521.
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. “A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.” Nat Immunol. 2006 7(1):40-48.
Ishii KJ, Akira S.“TLR ignores methylated RNA?” Immunity. 2005 23(2):111-3.
Ishii KJ, Akira S. “Innate immune recognition of nucleic acids: Beyond toll-like receptors.” Int J Cancer. 2005 117(4):517-23.
Ishii KJ, Ito S, Tamura T, Hemmi H, Conover J, Ozato K, Akira S, Klinman DM. “CpG-activated Thy1.2(+) dendritic cells protect against lethal Listeria monocytogenes infection.” Eur J Immunol. 2005 35(8):2397-405.
Ishii KJ, Gursel I, Gursel M and Klinman DM. “ Immunotherapeutic Utility of Stimulatory and Suppressive Oligonucleotides” Curr. Opin. Mol. Ther. 6(2):166-74, 2004.
Ishii KJ*, Kawakami K, Gursel I, Klinman DM and Puri RK. “Anti-tumor therapy with bacterial DNA and toxin: Liposomal CpG ODN plus IL-13 cytotoxin induces complete regression of established human tumor in animal models.” Clinical Cancer Research. 9(17): 6516-22, 2003.
Ishii KJ, Takeshita F, Gursel I, Gursel M, Nussenzweig A and Klinman DM. "Potential Role of PI3 Kinases, rather than DNA-PK, in CpG DNA Induced Immune Activation" J. Exp. Med. Jul 15;196(2):269-74, 2002.
Ishii KJ, Suzuki K, Itoh Y, Coban C, Takeshita F, Matoba H, Kohn LD, Klinman DM. “Genomic DNA released by dying cells induces the maturation of antigen presenting cells.” J. Immunol. 167(5): 2602-2607, 2001.
Klinman DM, Verthelyi D, Takeshita F, Ishii KJ. “Immune recognition of foreign DNA.” Immunity, Vol.11, 123 129, 1999.
Ishii KJ, Weiss WR, Ichino M, Verthelyi D, Hoffman SL, Klinman DM. “Activity and Safety of DNA Plasmids Encoding IL 4 and IFN gamma.” Gene Ther. 6: (2) 237 244, 1999.
Ishii KJ, Weiss WR, Klinman DM. “Prevention of neonatal tolerance by plasmid DNA encoding GMCSF.” Vaccine, Vol.18, 703-10, 1999.
著書
Ishii KJ and Tang CK (Editor in chief) “Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology” ELSEVIER, 2013
"Nucleic Acids in Innate Immunity" Edited by Ishii KJ and Akira S, CRC press, 2008.
受賞・表彰
2019 |
22nd JSI Award |
2014 |
32th Osaka Science Prize |
2014 |
‘Highly cited researcher’ in Thomson Reuters THE WORLD'S MOST INFLUENTIAL SCIENTIFIC MINDS 2014 |
2012 |
Thinking inside the box award DNA vaccines |
2010 |
Isamu Tagaya Memorial Vaccine Research Award |
2008 |
Japanese Society of Immunology, Young Investigator Award |
2007 |
‘Rising star in Immunology’(Sep 2007) Thompson Reuter’s ISI |