粘膜免疫学

Mucosal Immunology

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私たちの研究室では、クローン病や潰瘍性大腸炎などの炎症性腸疾患の病因・病態を解明するため、腸管の恒常性維持機構を下記の3つの柱を中心に解析しています。

主任研究者

竹田 潔 教授

研究内容:炎症性腸疾患の病因・病態解明をめざした腸管恒常性の維持機構の解析
06-6879-3980
ktakedaongene.med.osaka-u.ac.jp
学 歴

1992 大阪大学医学部卒業
1998 大阪大学大学院医学系研究科修了

職 歴

1998 兵庫医科大学生化学講座 助手
1999 大阪大学微生物病研究所 助手
2003 九州大学生体防御医学研究所 教授
2007 大阪大学大学院医学系研究科 教授
2019.7 大阪大学免疫学フロンティア研究センター拠点長

メンバー

梅本 英司 准教授
umemotoongene.med.osaka-u.ac.jp
香山 尚子 准教授
kayamaongene.med.osaka-u.ac.jp
奥村 龍 助教
okumuraongene.med.osaka-u.ac.jp
村上 真理 特任助教
marimongene.med.osaka-u.ac.jp
 
 

主な論文

Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, and Takeda K: Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol 10, 446-259 (2017)
Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K: Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheum. 68, 2646-2661 (2016).
Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K: Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532, 117-121 (2016).
Tsai, S. H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.: Ectoenzyme E-NPP3 (CD203c) negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity 42, 279-293 (2015).
Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M. Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M. and Takeda,K.: Generation of colonic IgA-secreting cells in the cecal patch. Nat. Commun. 5, 3704 (2014)
Ogino, T., Nishimura, J., Barman, S., Kayama, H., Uematsu, S., Haraguchi, N., Uemura, M., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Takeda, K., Doki, Y., and Mori, M.: Increased Th17-inducing activity of CD14(+) CD163(low) myeloid cells in intestinal lamina propria of patients with Crohn's disease. Gastroenterol. 145, 1380-1391 (2013).
Kimura, T., Katoh, H., Kayama, H., Saiga, H., Okuyama, M., Okamoto, T., Umemoto, E., Matsuura, Y., Yamamoto, M. and Takeda, K.: Ifit1 inhibits JEV replication through binding to 5' capped 2'-O unmethylated RNA. J. Virol. 87, 9997-10003 (2013).
Kusu, T., Kayama, H., Kinoshita, M., Jeon, S.G., Ueda, Y., Goto, Y., Okumura, R., Saiga, H., Kurakawa, T., Ikeda, K., Maeda, Y., Nishimura, J., Arima, Y., Atarashi, K., Honda, K., Murakami, M., Kunisawa, J., Kiyono, H., Okumura, M., Yamamoto, M., and Takeda, K.: ENTPDase7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J. Immunol. 190, 774-783 (2013).
Kinoshita, M., Kayama, H., Kusu, T., Yamaguchi, T., Kunisawa, J., Kiyono, H., Sakaguchi, S. and Takeda, K.: Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J. Immunol. 189, 2869-2878 (2012).
Yamamoto, M., Okuyama, M., Ma, J. S., Kimura, T., Kamiyama, N., Saiga, H., Ohshima, J., Kayama, H., Okamoto, T., Huang, D. C. S., Soldati-Farve, D., Horie, K., Takeda, J. and Takeda, K.: A cluster of IFN--inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity 37, 302-313 (2012).
Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., Okumura, R., Hara, H., Yoshida, H., Yamamoto, M., Nomoto, K. and Takeda, K.: Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathogens 8, e1002714 (2012).
Kayama, H., Ueda, Y., Sawa, Y., Jeon, S. G., Ma, J. S., Okumura, R., Kubo, A., Ishii, M., Okazaki, T., Murakami, M., Yamamoto, M., Yagita, H. and Takeda, K.: Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109, 5010-5015 (2012).
Yamamoto, M., Ma, J. S., Mueller, C., Kamiyama, N., Saiga, H., Kubo, E., Kimura, T., Okamoto, T., Okuyama, M.., Kayama, H., Nagamune, K., Takashima, S., Matsuura, Y., Soldati-Farve, D. and Takeda, K.: ATF6 is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J. Exp. Med. 208, 1533-1546 (2011).
Yamamoto, M., Standley, D.M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., Soldati-Farve, D., and Takeda, K.: A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J. Exp.Med. 206, 2747-2760 (2009).
Kayama, H., Koga, R., Atarashi, K., Mak, T. W., Takayanagi, H., Honda, K., Yamamoto, M. and Takeda, K.: NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. PLoS Pathogens 5, e1000514 (2009).
Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., and Takeda, K.: ATP drives lamina propria TH17 cell differentiation. Nature 455, 808-812 (2008).
Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., and Takeda, K.: Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IB. J. Biol. Chem. 283, 12468-12477 (2008).
Koga, R., Hamano, S., Kuwata, H., Atarashi, K., Ogawa, M., Hisaeda, H., Yamamoto, M., Akira, S., Himeno, K., Matsumoto, M., and Takeda, K.: TLR-dependent induction of IFN- mediates host defense against Trypanosoma cruzi. J. Immunol. 177, 7059-7066 (2006).
Kuwata, H., Matsumoto, M., Atarashi, K., Morishita, H., Hirotani, T., Koga, R., and Takeda, K.: IBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity 24, 41-51 (2006).

受賞・表彰

2004 第7回日本免疫学会賞
2009 第6回日本学術振興会賞
2016 第34回大阪科学賞
2016 第53回ベルツ賞