主な論文
Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc Natl Acad Sci U S A. 114(10): 2681-2686 (2017)
Satoh T, Nakagawa K, Sugihara F, Kuwahara R, Ashihara M, Yamane F, Minowa Y, Fukushima K, Ebina I, Yoshioka Y, Kumanogoh A, Akira S. Identification of an atypical monocyte and committed progenitor involved in fibrosis. Nature. 541(7635):96-101 (2017)
Satoh T, Akira S. Toll-Like Receptor Signaling and Its Inducible Proteins. Microbiol Spectr. 6, 4 (2016)
Maeda K, Akira S. TLR7 Structure: Cut in Z-Loop. Immunity. 45(4):705-707 (2016)
Martino MM, Maruyama K, Kuhn GA, Satoh T, Takeuchi O, Muller R, Akira S. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration. Nature Communications. 7:11051 (2016)
Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T. Pivotal role of RNA-binding E3 ubiquitin ligase mEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A. 111(15):5646-5651 (2014)
Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T, Akira S. Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc Natl Acad Sci U S A. 110(30):12379-12384 (2013)
Uehata T, Iwasaki H, Vandenbon A, Matsushita K, Hernandez-Cuellar E, Kuniyoshi K, Satoh T, Mino T, Suzuki Y, Standley DM, Tsujimura T, Rakugi H, Isaka Y, Takeuchi O, Akira S. Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation. Cell. 153(5):1036-1049 (2013)
Zou J, Kawai T, Tsuchida T, Kozaki T, Tanaka H, Shin KS, Kumar H, Akira S. Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis. Immunity. 38(49):717-728 (2013)
Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature. 495(7442):524-528 (2013)
Misawa T, Takahama M, Kozaki T, LeeH, Zou J, Saitoh T, Akira S. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 14(5):454-460 (2013)
Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S. The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol. 12(12):1167-1175 (2011)
Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S. Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. Immunity. 34(3):352-63 (2011)
Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S. The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. Immunity. 33(5):765-776 (2010)
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 11(10):936-944 (2010)
Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 107(4):1512-1517 (2010)
Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A. 106(49):20842-20846 (2009)
Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S. TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol. 10(9):965-972 (2009)
Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 458(7242):1185-1190 (2009)
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 456(7219):264-268 (2008)
受賞・表彰
2012 |
フレデリックバンアワード(IEIIS) |
2011 |
ガードナー国際賞 |
2011 |
吹田市長賞 |
2010 |
慶應医学賞 |
2010 |
アベリー・ランドスタイナー賞(ドイツ免疫学会) |
2009 |
文化功労者・顕彰 |
2007 |
ミルシュタイン賞(ICIS) |
2007 |
恩賜賞・日本学士院賞 |
2007 |
上原賞 |
2007 |
リサーチフロントアワード(トムソン・ロイター) |
2006 |
ウィリアム・コーリー賞(米国がん研究所) |
2006 |
朝日賞 |
2005 |
紫綬褒章 |
2004 |
ロベルト・コッホ賞(ドイツ・コッホ財団) |
2004 |
高松宮妃癌研究基金学術賞 |
2003 |
武田医学賞 |
2002 |
大阪科学賞 |
2001 |
野口英世記念医学賞 |
2000 |
井上学術賞 |
その他
アカデミー会員
2014 |
日本学士院・会員 |
2010 |
EMBO・外国人会員 |
2010 |
米国微生物学会・アカデミー会員 |
2009 |
米国科学アカデミー・外国人会員 |
雑誌編集委員
- Microbes and Infection (Editor)
- Journal of Experimental Medicine (Advisory Editor)
- BMC Immunology (Editorial Advisor)
- Current Immunology Reviews (Editorial Board)
- Current Opinion in Immunology (Editorial Board)
- Immunity (Editorial Board)
- Immunology (Editorial Board)
- International Immunology (Editor-in-Chief)
特記
2016 |
Highly Cited Researchers “Biology & Biochemistry, Immunology” (Thomson Reuters) |
2014 |
Highly Cited Researchers “Biology & Biochemistry”, “Clinical Medicine”, “Immunology” (Thomson Reuters) |
2014 |
Lerner Lecture (Cleveland Clinic Lerner Research Institute, USA) |
2014 |
Distinguished LUDWIG Lecture (Universite de Lausanne, Germany) |
2010 |
17th Dundee Cell Signaling Lecture (University of Dundee, Scotland) |
2009 |
Lacey Lecture (Washington University at St. Louis, Germany) |
2008 |
Dyer Lecture (National Institutes of Health, USA) |
2007 |
Dunham Lectures (Harvard Medical School, USA) |
2007 |
ミュンヘン工科大学名誉医学博士 |
2006-2007 |
"Hottest Researchers"第4位(Thomson Scientific) |
2005-2006 |
"Hottest Researchers"第1位(Thomson Scientific) |
2004-2005 |
"Hottest Researchers"第1位(Thomson Scientific) |
2003-2004 |
"Hottest Researchers"第8位(Thomson Scientific) |
過去10年間での発表論文の総引用回数、2004年以降免疫学分野で第1位(Thomson Scientific)