News & Topics

Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases (Okada G, in Nat Commun.)

A newly identified type II interferon-related subset for predicting relapse of autoimmune small vessel vasculitis (Nishide-Kumanogoh G, in Nat Commun.)

A new therapy for acute myeloid leukemia (Hosen G, in Nat Cancer)

RBPJ ablation in T cells boosts iTreg differentiation, stability and function (Sakaguchi G, in Nature)

KLF2 expression in IgG plasma cells regulates the migration program (Ise-Kurosaki, in JEM)

Contribution of germline and somatic mutations to risk of NMOSD (Okada G, in Cell Gen.)

Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer (Okada G, in Nat Commun.)

A New T cell Subset Fighting Mycobacterium Tuberculosis (Yamasaki G, in JCI)

Blood DNA virome associates with autoimmune diseases and COVID-19 (Okada G, in Nat Gen.)

Identification of alpha-galactosylceramide as an endogenous mammalian antigen for iNKT cells (Yamasaki G, in JEM)

Platelet factor 4-induced Th1-Treg polarization suppresses anti-tumor immunity (Yamamoto G, in Science)

Groundbreaking articles from IFReC have graced the cover of journals.

Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution (Segawa & Nagata G, in Nat Strct Mol Biol.)

Substrate specificity controlled by the human P4-ATPases in neurological disorders (Nagata G, in PNAS)

Pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells (Takeda G, in PNAS)

Neoself-antigens are the primary target for autoreactive T cells in human lupus (Arase G, in Cell)

Local administration of Tregs promotes tissue healing (Martino & Akira G, in Nat Commun)

Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells (Ichiyama-Sakaguchi G, in Immunity)

Quantification of escape from X chromosome reveals heterogeneity across cell types and tissues (Okada G, in Cell Gen.)

SEMA6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs (Kang-Kumanogoh G, in Neuron)

Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice (Kumanogoh G, in Nat Rev Immunol.)

Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses (Okada G, in Nat Gen.)

SFTPB as a biomarker of progressive pulmonary fibrosis (Kumanogoh G, in JCI Insight)

Deletion of Regnase-1 promotes NK cell anti-tumor activity (Akira G, in Immunity)

Far-East Asian Toxoplasma isolates share ancestry with American recombinant lineages (Yamamoto G, in Nat Commun.)

Understanding the mechanism for B cell selection (Inoue-Kurosaki G, in JEM)

Periportal macrophages protect against commensal-driven liver inflammation (M Ishii G, in Nature)

Threonine phosphorylation and the Yin and Yang of STAT1 in Inflammatory Responses (Hozaifa-Kishimoto G, in PNAS)

Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology (Kumanogoh G, in JACI）

CGRP sensory neurons promote tissue healing via immune cells (Martino & Akira G, in Nature)