News & Topics

HOME > News & Topics > Research > FY 2008 > ATP drives lamina propria TH17 cell differentiation. (Prof. Takeda and Associate Prof. Honda in Nature)

ATP drives lamina propria TH17 cell differentiation. (Prof. Takeda and Associate Prof. Honda in Nature)

Prof. Takeda's group shows that adenosine 5'-triphosphate (ATP) derived from commensal bacteria activates a unique subset of lamina propria cells, CD70highCD11clow cells, leading to the differentiation of TH17 cells, Interleukin (IL)-17-producing CD4+ T lymphocytes.

This study explains the importance of commensal bacteria and ATP for immunological diseases, because several immune disorders are promoted by the existence of inflammatory cytokines such as IL-17 produced from TH17.

Article


Contact:

Kiyoshi Takeda
Laboratory of Immune Regulation,
Osaka University Graduate School of Medicine C6
(Laboratory of Mucosal Immunology, Immunology Frontier Research Center)
2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan

Tel: +81-6-6879-3982   Fax: +81-6-6879-3989
E-mail: ktakeda@ongene.med.osaka-u.ac.jp

Archives

 
TOPに戻る