Prof. Takeda's group shows that adenosine 5'-triphosphate (ATP) derived from commensal bacteria activates a unique subset of lamina propria cells, CD70^highCD11c^low cells, leading to the differentiation of T_H17 cells, Interleukin (IL)-17-producing CD4⁺ T lymphocytes.

This study explains the importance of commensal bacteria and ATP for immunological diseases, because several immune disorders are promoted by the existence of inflammatory cytokines such as IL-17 produced from T_H17.

Article

Contact:

Kiyoshi Takeda
Laboratory of Immune Regulation,
Osaka University Graduate School of Medicine C6
（Laboratory of Mucosal Immunology, Immunology Frontier Research Center)
2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan

Tel: +81-6-6879-3982 　 Fax: +81-6-6879-3989
E-mail: ktakeda@ongene.med.osaka-u.ac.jp