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Research FY 2008

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. (Shizuo AKIRA & Daron STANDLEY in Nature)
Hepatic Interleukin-7 Expression Regulates T Cell Responses. (Associate Prof. Masaaki Murakami in Immunity)
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. (Associate Prof. Masaru Ishii in Nature)
Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase Cq Translocation (Prof. Saito in Immunity)
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. (Assistant Prof. Saitoh and Prof. Akira)
CTLA-4 Control over Foxp3+ Regulatory T Cell Function. (Prof. Sakaguchi in Science)
Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. (Associate Prof. Murakami and Prof. Hirano in Immunity)
Mincle is an ITAM-coupled activating receptor that senses damaged cells. (Prof. Saito in Nature Immunology)
GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (Associate Prof. Maeda in Nature Cell Biology)
ATP drives lamina propria TH17 cell differentiation. (Prof. Takeda and Associate Prof. Honda in Nature)
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5 (Prof. Akira and Dr. Kato in
Regulatory T Cells and Immune Tolerance (Review by Prof. Sakaguchi in Cell)
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 (Prof. Akira and Assistant Prof. Uematsu in Nature Immunology)