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Research FY 2013

Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility (Hisashi ARASE in PNAS)
Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist (Ken ISHII in PNAS)
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP (Shizuo AKIRA in JEM)
The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling (Shizuo AKIRA in Cell Host & Microbe)
Repression of Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation. (Tomohiro KUROSAKI in Immunity)
Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation. (Shizuo AKIRA in Cell)
Arid5a controls IL-6mRNA stability, which contributes to elevation of IL-6 level in vivo. (Tadamitsu KISHIMOTO in PNAS)
The double stranded RNA poly IC triggers a cathepsin D-IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis (Shizuo AKIRA in Immunity)
S1P-mediated osteoclast precursor monocyte migration is a critical point of control in anti-bone-resorptive actions of active vitamin D. (Masaru ISHII in PNAS)