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Peripherally derived FGF21 promotes remyelination in the central nervous system (Yamashita group, in JCI)
Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions (Masaru Ishii group, in Scientific Reports)
A distinct subpopulation of CD25 negative T-follicular regulatory cells localizes in the germinal centers (Sakaguchi group, in PNAS)
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense (Yamamoto group, in Nature Immunology)
Plasmodium products persist in the bone marrow and promote chronic bone loss (Coban group, in Science Immunology)
BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection (Takeda group, in JEM)
The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help (Kurosaki group, in JEM)
Identification of an atypical monocyte and committed progenitor involved in fibrosis (Akira group, in Nature)
Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin 1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation (Ken Ishii group, in Immunity)
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment (Sakaguchi group, in Nat Immunol)
Diurnal control of adaptive immune responses by adrenergic nerves (Suzuki group, in JEM)
Arid5a exacerbates IFN-γ-mediated septic shock by stabilizing T-bet mRNA (Kishimoto group, in PNAS)
Rabex-5 is a Lenalidomide target molecule that negatively regulates TLR induced type-1 interferon production (Kishimoto group, in PNAS)
Real-time intravital imaging of pH variation associated with osteoclast activity (Kikuchi group and M. Ishii group, in Nat Chem Biol)
Regulated selection of germinal-center cells into the memory B cell compartment (Kurosaki group, in Nat Immunol)
Two FOXP3+CD4+ T-cell subpopulations distinctly control the prognosis of colorectal cancers (Sakaguchi group, in Nat Med)
Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia (TAKEDA group, in Nature)
p62 plays a specific role in interferon-γ-induced presentation of a Toxoplasma vacuolar antigen (Masahiro Yamamoto in Cell Reports)
CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability(Tomohiro Kurosaki in JEM)
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii(Masahiro Yamamoto in PNAS)
Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging (Hideaki Fujita in Scientific Reports)
Visualized macrophage dynamics and significance of S100A8 in obese fat (Masaru ISHII in PNAS)
β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome (Hisashi ARASE in Blood)
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine- producing metabolic pathway (Masaru ISHII in Nat Med)
The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells (Kiyoshi TAKEDA in Immunity)
Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4 (Shimon SAKAGUCHI in Immunity)
Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals (Shimon SAKAGUCHI in Science)
Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation (Tomohiro KUROSAKI in Immmunity)