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Research FY 2011

Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival (TOYOFUKU & KUMANOGOH in Genes and Development)
Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis.
(Kiyoshi TAKEDA in PNAS)
Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. (Masaaki MURAKAMI in Cell)
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. (Shizuo AKIRA in Nat Immunol.)
The article by Dr. Noel Verjan & Prof. Miyasaka was featured in "In This Issue" of The Journal of Immunology.
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis (Tadamitsu Kishimoto in PNAS)
DNA released from dying host cells mediates aluminum adjuvant activity. (Ken Ishii in Nature Medicine)
CIN85 drives B cell responses by linking BCR signals to the canonical NF- kB pathway. (Tomohiro Kurosaki in JEM)
ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18. (Kiyoshi Takeda & Masahiro Yamamoto in JEM)
Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. (Tatsuya Saitoh & Shizuo Akira in Immunity)
The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production. (Yoshihiro Baba & Tomohiro Kurosaki in Immunity)
ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation. (Prof. Kurosaki in Science Signal.)