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Research FY 2010

Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. (Associate Prof. Murakami & Prof. Hirano in JEM)
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. (Associate Prof. Masaru Ishii in JEM)
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. (Associate Prof. Kawai & Prof. Akira in Immunity)
Structural basis for semaphorin signalling through the plexin receptor. (Profs Takagi (IPR) & Kumanogoh (IFReC) in Nature)
Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation. (Prof. Saito in Immunity)
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. (Prof. Akira in Nature Immunology)
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II (Prof. Kumanogoh in Nature Immunology)
Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes (Profs Akira & Ken Ishii in Science Translational Medicine)