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Research FY 2014

β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome (Hisashi ARASE in Blood)
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine- producing metabolic pathway (Masaru ISHII in Nat Med)
The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells (Kiyoshi TAKEDA in Immunity)
Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4 (Shimon SAKAGUCHI in Immunity)
Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals (Shimon SAKAGUCHI in Science)
Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation (Tomohiro KUROSAKI in Immmunity)
Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors (Kazuhiro SUZUKI in JEM)
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease (Shimon SAKAGUCHI in Science)
Laser-targeted photofabrication of gold nanoparticles inside cells (Nicholas SMITH in Nat Commun)
Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6 (Masahiro YAMAMOTO in JEM)
Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells (Tomohiro KUROSAKI in PNAS)
Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR-alpha (Hisashi ARASE in PNAS)
Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria (Cevayir COBAN in Cell Host & Microbe)
Generation of colonic IgA-secreting cells in the cecal patch (Kiyoshi TAKEDA in Nat Commun)
Nucleic acid sensing by T cells initiates Th2 cell differentiation (Takashi SAITO in Nat Commun)