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HOME > News & Topics > Research > FY 2014 > Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4 (Shimon SAKAGUCHI in Immunity)

Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4 (Shimon SAKAGUCHI in Immunity)

The authors found Treg cells directly inhibited, via CTLA-4, B cell expression of CD80 and CD86, which was essential for Tfh cell formation.



Wing・Sakaguchi IMMUNITY_20141219.pdf


Article


Contact:

Shimon SAKAGUCHI
Experimental Immunology
Immunology Frontier Research Center (WPI-IFReC), Osaka University

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