Shimon Sakaguchi's group (Experimental Immunology) and others revealed that Colorectal cancers (CRCs), which are commonly infiltrated by suppression-competent FOXP3^hi regulatory T (Treg) cells, can be classified into two types by the degree of additional infiltration of FOXP3^lo nonsuppressive T cells. CRCs with abundant　infiltration of FOXP3 ^lo T cells showed significantly better prognosis than those with predominantly FOXP3^hi Treg cell infiltration.
The results found an effective way to distinguish target patients of cancer immunotherapy for CRCs, and will contribute to the development of cancer immunotherapy targeting Treg cells.

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Contact:

Hiroyoshi Nishikawa
Experimental Immunology
Immunology Frontier Research Center (WPI-IFReC), Osaka University

Shimon Sakaguchi
Experimental Immunology
Immunology Frontier Research Center (WPI-IFReC), Osaka University