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Identification of an atypical monocyte and committed progenitor involved in fibrosis (Akira group, in Nature)

Akira's group (Host Defense) identified an atypical monocyte and committed progenitor involved in fibrosis.
The group termed the identified monocytes Segregated nucleus Atypical Monocytes (SatM). They found that SatM have a bi-lobed segmented nuclear shape and many cytoplasmic granules, and are regulated by C/EBPβ. The development of fibrosis was prevented in chimeric mice with C/EBPβ knockout hematopoietic cells, indicating that SatM are critical for fibrosis. They also identified SatM progenitor cells, and their results show that C/EBPβ licences differentiation of SatM from their committed progenitor.
Given that 'disorder-specific monocyte/macrophage subtypes' corresponding to certain diseases have been identified, investigated and regulated, it may also now be possible to develop novel, more specific therapeutic targets with fewer side effects.




Article (External Link)


Contact:
Shizuo Akira
Host Defense
Immunology Frontier Research Center (WPI-IFReC), Osaka University

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