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Research
2018.05.24

Autoimmune Th17 cells induced synovial stromal and innate lymphoid cell secretion of GM-CSF to initiate and augment autoimmune arthritis (Sakaguchi Group, in Immunity)

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Hirota and Sakaguchi's group showed arthritogenic Th17 cells stimulated fibroblast-like synoviocytes via interleukin-17 (IL-17) to secrete the cytokine GM-CSF and also expanded synovial-resident innate lymphoid cells (ILCs) in inflamed joints.

Figure1



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Contact:
Shimon Sakaguchi

Shimon Sakaguchi (Experimental Immunology）


Tel+81-6-6879-4462
Mailshimonifrec.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)
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