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Heme ameliorates the colitis through providing intestinal macrophages with non-inflammatory profiles (Takeda group, in PNAS)

Hisakao Kayama, Masako Kohyama, and Kiyoshi Takeda group show heme regulates gut homeostasis through induction of Spi-C in intestinal CX3CR1high Macrophages.

 figure Mechanism of the regulation for the intestinal macrophages.
The heme-induced transcription factor Spi-C inhibits the dimer formation
of transcription factors IRF5 and NF-κB p65. As a result,
the expression of some TLR4-dependent genes is suppressed.



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Contact:
Kiyoshi Takeda

Kiyoshi Takeda(Mucosal Immunology)


Tel+81-6-6879-3980
Mail ktakedaongene.med.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)

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