Hisakao Kayama, Masako Kohyama, and Kiyoshi Takeda group show heme regulates gut homeostasis through induction of Spi-C in intestinal CX3CR1high Macrophages.

　 Mechanism of the regulation for the intestinal macrophages.
The heme-induced transcription factor Spi-C inhibits the dimer formation
of transcription factors IRF5 and NF-κB p65. As a result,
the expression of some TLR4-dependent genes is suppressed.

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Kiyoshi Takeda（Mucosal Immunology）

+81-6-6879-3980
ktakedaongene.med.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)