Hisamichi Naito, Nobuyuki Takakura (Signal Transduction, IFReC and RIMD) and their research group showed that TGFβ-activated kinase 1 (TAK1) ensures EC survival and maintains vascular integrity upon TNFα stimulation.

Endothelial-specific TAK1 knockout mice exhibit intestinal and liver hemorrhage due to EC apoptosis, leading to vascular destruction and rapid death. The EC apoptosis was induced by TNFα from myeloid cells responding to intestinal microbiota.

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Contact:

Nobuyuki Takakura（Signal Transduction）

06-6879-8316
ntakakubiken.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)