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Structural basis for RIFIN-mediated activation of LILRB1 in malaria (Arase G, in Nature)

The research group of Hisashi Arase (Immunochemistry, IFReC/RIMD, Osaka University) and University of Oxford determined a structure of a RIFIN bound to LILRB1, and showed the RIFIN mimics the natural activating ligand of LILRB1, MHC class I, in its LILRB1-binding mode.

figure 1 Fig.1 Mechanism of immune escape by P. falciparum (Saito et al. Nature 2017).

figure 2 Fig. 2 Binding structure of LILRB1-binding RIFIN (L) and LILRB1-binding MHC I (R).



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Contact:

Hisashi Arase (Immunochemistry)

Tel+81-6-6879-8291
Mail arase@biken.osaka-u.ac.jp
WPI Osaka University Immunology Frontier Research Center

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